The affinity of various corneal boundary surfaces, such as mucus-coated epithelium, demucinized epithelium, denuded basement membrane, and keratectomized cornea, to water and hydrophobic liquids was determined by contact angle goniometry on enucleated rabbit eyes. The mucus-coated surface and the bare stromal surface without the basement membrane were found to be more hydrophilic than the surfa...

OBJECTIVE To investigate the conjunctival and nasal flora and the antibiotic susceptibility profiles of isolates from patients undergoing cataract surgery. DESIGN Observational and cross-sectional study. SETTING A single-centre study in Taiwan. PARTICIPANTS 128 consecutive patients precataract surgery. PRIMARY AND SECONDARY OUTCOME MEASURES METHODS Conjunctival and nasal cultures were p...

Agmatine, an endogenous polyamine and putative neuromodulator, is known to have neuroprotective effects on various neurons in the central nervous system. We determined whether or not topically administered agmatine could reduce ischemic retinal injury. Transient ocular ischemia was achieved by intraluminal occlusion of the middle cerebral artery of ddY mice (30-35 g) for 2 h, which is known to ...

BACKGROUND In vitro studies have suggested the corneal cytotoxicity of third-generation fluoroquinolone levofloxacin (LVFX) and fourth-generation fluoroquinolone moxifloxacin hydrochloride (MFLX) among fluoroquinolone antibacterial eye drops. This study investigated the effects of these two eye drops on the human cornea in vivo. METHODS We evaluated 30 healthy adults (19 men and 11 women, 38....

When two masked targets (T1 and T2), both requiring attention, are presented within half a second of each other, report of the second target is poor, demonstrating an attentional blink (AB). Potter, Chun, Banks, and Muckenhoupt (1998) argued that all previous demonstrations of an AB occurring when one or more targets were presented outside the visual modality did not represent true AB but were,...

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4 Overview of the Thesis 11

Topical administration of a drug in the conjunctival cul-de-sac is the treatment of choice for diseases of the anterior segment of eye. Development of ophthalmic drug delivery systems has always been challenging because of the drawbacks with this route, like non-productive absorption, drainage, induced lacrimation, tear turn over, impermeability of drugs to cornea. New approaches have been inve...