1 May 2018 T HIS study was motivated by two imperatives. First, the ongoing epidemics of opiate abuse1 and obesity2 reinforce our interest in opiate research with potential for translational relevance.3–12 Second, opiate-induced alterations in the ventilatory response to hypercapnia are sexually dimorphic,13 consistent with evidence that respiratory control is altered by sex steroid hormones.14...

Opiate dependence remains a fundamental challenge confronting health delivery systems and is often characterized as a social and moral issue. The impact of this disorder on healthcare policy is changing with the increased incidence of HIV, hepatitis C, and tuberculosis infections in opiate-dependent patients. These medical illnesses have substantial effect on escalating healthcare costs, and, t...

Abstract Background: Methadone maintenance therapy is a treatment of choice for opiate addiction. Understanding opiate dependents’ experiences of patients' treatment is a key to continue the treatment and can provide help to revise the standards of methadone centers and improve the quality of treatment. This study aimed to describe the essence and structure of opiate dependents’ e...

BACKGROUND Hepatitis B, hepatitis C and HIV infections constitute serious healthcare problems worldwide. OBJECTIVES There are a limited number of studies regarding the prevalence of hepatitis B, hepatitis C and HIV infections among the drug addicts in Turkey; hence, the current study aimed to determine the frequency of these infections among 235 drug addicts treated in a drug addiction treatm...

Stress sensitization, whereby CA lowers tolerance to later stressors, has been proposed as a potential mechanism explaining the association between exposure to childhood adversities (CA) and drug use disorders in adulthood. However, this mechanism remains untested. This paper begins to address this gap through exploring associations between CA exposure and stressful events in adulthood for pred...

Withdrawal from opiates, such as heroin or oral narcotics, is characterized by a host of aversive physical and emotional symptoms. High rates of relapse and limited treatment success rates for opiate addiction have prompted a search for new approaches. For many opiate addicts, achieving abstinence may be further complicated by poly-drug use and co-morbid mental disorders. Research over the past...

Antithrombin III activity was significantly decreased in opiate addicts, but no difference was found between addict and control groups in antithrombin III plasma concentration. Moreover, glycosylated haemoglobin concentration was increased in opiate addicts, but no correlation between glycosylated haemoglobin and antithrombin III activity was found. These data show that in opiate addicts there ...

In this communication we show that T cell locomotion is affected by direct interaction with neurohormones. Opioid peptides, including beta-END, MET-ENK, LEU-ENK, and related enkephalin analogues enhanced migration of human peripheral blood T lymphocytes. Activity was dependent on the peptide NH2-terminal sequence, stimulated by enkephalin analogues with specificity for classical delta or mu typ...

BACKGROUND To date there have been no studies estimating the hidden prevalence of opiate use in Dublin. METHODS A multisource enumeration followed by the application of the capture-recapture method with log-linear modelling including age and gender stratification to remove heterogeneity was implemented to provide an estimate of the unknown size of the opiate-using population. Two medical and ...

This article explores the evolving evidence supporting the provision of opioid maintenance therapies to incarcerated populations.