BACKGROUND Though patients in opiate substitution programs are commonly infected with HCV, due to safety and efficacy concerns, they are rarely treated with interferon and ribavirin. METHODS In a multicenter study, HCV-infected patients in opiate maintenance treatment programs received 180 microg pegylated interferon-alfa-2a once weekly, plus daily ribavirin for 24 weeks (genotypes 2, 3), or ...

AIMS The aim of this study was to examine the effect of a case management intervention on retention in opiate agonist therapy among injection drug users (IDUs) referred from a needle exchange program (NEP). DESIGN, INTERVENTION, PARTICIPANTS, AND SETTING: A randomized trial of a strengths-based case management intervention versus passive referral (control) was conducted among NEP attendees requ...

The GM-MDS conjecture of Dau et al. (ISIT 2014) speculates that the MDS condition, which guarantees the existence of MDS matrices with a prescribed set of zeros over large fields, is in fact sufficient for existence of such matrices over small fields. We prove this conjecture.

SUMMARY Despite record-breaking numbers of opiate related deaths in the UK 2019, pharmacological management dependence has evolved little since advent methadone 1965. Along with harm minimisation and psychosocial interventions, mainstay treatment remains opioid substitution therapy (OST) using or buprenorphine, many patients receiving OST for years. Even these treatments, users continue to face...

background illicit opiate use has an increasing incidence and prevalence, which increases mortality and morbidity, marginalization, and criminal behaviors, and causes major adverse effects on society. objectives this study aimed to investigate and follow the outcome of patients who underwent ultrarapid opiate detoxification (urod) prospectively. patients and methods in this randomized clinical ...

BACKGROUND Non-fatal overdose is a major determinant of morbidity among injection drug users (IDU). We sought to evaluate factors associated with non-fatal overdose among IDU in Vancouver. METHODS We examined non-fatal overdose among participants in the Vancouver Injection Drug Users Study. Correlates of non-fatal overdose occurring between 1996 and 2004 were identified using generalized esti...

Purpose. The objective of this study was to document the number of controlled substance prescriptions filled by adolescents and young adult patients in the 2 years prior to presentation for opiate dependence treatment. Methods. Opiate-dependent youth (N = 125) presenting to our Medication-Assisted Treatment for Addiction program from January 1, 2008 to June 30, 2010 were identified via electron...

noradrenaline release.8.9 While clonidine and the opiates have similar effects on the locus coeruleus, clonidine appears to exert specific effects through non-opiate, alpha-2 adrenergic receptors. 6, These data suggested that the opiate-withdrawal syndrome is due to increased noradrenergic neuronal activity in areas such as the locus coeruleus which are regulated both by alpha-2 adrenergic and ...

INTRODUCTION Naloxone, an opiate antagonist that can avert opiate overdose morality, has long been prescribed to drug users in Europe and in a few US cities. However, there has been little documented evidence of naloxone distribution programs and their feasibility in the peer reviewed literature in the US. METHODS A pilot overdose prevention and reversal program was implemented in a New York ...

BACKGROUND Specialist drug treatment is critical to overdose prevention; methadone maintenance is effective, but we lack evidence for other modalities. We evaluate the impact of a range of treatments for opiate dependence on overdose mortality. METHODS Prospective cohort study of 10,454 heroin users entering treatment 1998-2001 in Italy followed-up for 10,208 person-years in treatment and 2,9...