BACKGROUND Malignant optic and chiasmatic gliomas are extremely rare, and are classified pathologically as anaplastic astrocytoma or glioblastoma multiforme (GBM). Approximately 40 cases of optic GBM in adults have been reported in the literature, and only five of them were described to originate from the optic chiasm. CASE DESCRIPTION An 82-year-old male patient with a past medical history o...

Expression of Nogo protein was investigated in the optic pathway of embryonic mice by using isoform-specific antibodies Bianca and 11C7, which recognize Nogo-A/B and Nogo-A, respectively. Our previous reports from using antibody N18 have shown that Nogo is localized on the radial glia in the retina and at the midline of the ventral diencephalon in mouse embryos during the ingrowth of retinal ga...

Traumatic chiasmal syndrome is one of the rare etiologies syndrome, characterized by optic chiasm injury following head trauma. The main visual defect associated bitemporal hemianopia with macular splitting; however, it can present a variety other defects and neurologic signs. authors report case complete after trauma, multiple frontal skull base fractures no deficits, or hypothalamic-pituitary...

Eleven eyes with lesions of the optic nerve and chiasm and 5 normal eyes were histologically studied and cells of the inner nuclear layer were counted in specific meridians. There was consistent decreased cellularity in the 9 eyes in tohich lesions of the optic nerve had been present for 2 years or longer. The probability that the decreased celhdarity occurred by chance ivas less than 0.02. Ret...

CASE REPORT We report a rare complication of retrobulbar anesthesia in ophthalmic surgery-amarurosis and extraocular muscle palsies in the contralateral eye. Our patient did not suffer permanent sequelae from the injection. DISCUSSION Numerous complications resulting from retrobulbar injections in the eye and orbit have been reported. One possible explanation of this case is the inadvertent p...

When optic fibers first approach the chiasmatic region of the diencephalon in the chick embryo on days 3 and 4 (E3-4), they rarely grow rostrally into the olfactory region of the telencephalon. Conversely, olfactory tract axons grow as far as, but never cross the diencephalic/telencephalic (D/T) boundary to enter the optic chiasm. In this study, a region of specialized neuroepithelium, original...

To determine whether diffusible guidance cues direct retinal axon growth and divergence at the optic chiasm, we cocultured mouse retinal and chiasm explants in collagen gels. The chiasm reduced retinal neurite lengths and numbers, but did not affect commissural or pontine neurite growth. This reduction in growth was equal for all retinal quadrants and occurred without reorienting the direction ...