Anthropogenic global changes threaten species and the ecosystem services upon which society depends. Effective solutions to this multifaceted crisis need scientific responses spanning disciplines and spatial scales. Macroecology develops broad-scale predictions of species' distributions and abundances, complementing the frequently local focus of global change biology. Macroecological discoverie...

Recent advances in global population data are enabling new cartographic and analytical opportunities. The Global Human Settlement Layer is the first sub-1 km cell resolution global population density product released as open data, with many applications in the fields of global population dynamics, urban studies and natural hazard risk. There are several cartographic challenges with visualising ...

What governs the concentrations of metabolites within living cells? Beyond specific metabolic and enzymatic considerations, are there global trends that affect their values? We hypothesize that the physico-chemical properties of metabolites considerably affect their in-vivo concentrations. The recently achieved experimental capability to measure the concentrations of many metabolites simultaneo...

Laboratory studies were conducted to investigate scrap-tire-shreds as a potential alternative to conventional gravel in the drainage layer of leachate collection system at the base of landfill. Performance of various physico-chemical characteristics of leachate after passing it through combined bed of scrap-tire-shreds and gravel for different combinations of thickness of scrap-tireshreds and g...

The goal of multiscale modeling in biology is to use structurally based physico-chemical models to integrate across temporal and spatial scales of biology and thereby improve mechanistic understanding of, for example, how a single mutation can alter organism-scale phenotypes. This approach may also inform therapeutic strategies or identify candidate drug targets that might otherwise have been o...

aim : we evaluated the effectiveness of a synbiotic in the treatment of childhood functional abdominal pain (fap). background: probiotics are effective in the treatment of functional gastrointestinal disorders in adult patients, but there is lack of information in children. patients and methods: children with fap, based on the rome iii criteria ( n = 115, aged 6-18 years), were randomized to re...

One of the most important aspects of visual attention is its flexibility; our attentional "window" can be tuned to different spatial scales, allowing us to perceive large-scale global patterns and local features effortlessly. We investigated whether the perception of global and local motion competes for a common attentional resource. Subjects viewed arrays of individual moving Gabors that group...

BACKGROUND Many women of reproductive age have depression, necessitating therapy with either a tricyclic antidepressant drug or a drug, such as fluoxetine, that inhibits the reuptake of serotonin. Whether these drugs affect fetal neurodevelopment is not known. METHODS We studied the children of 80 mothers who had received a tricyclic antidepressant drug during pregnancy, 55 children whose mot...

EACH PHASE IN THE LONG history ofthe world economy raises specific questions about the particular conditions that make it possible. One ofthe key properties ofthe current phase is the ascendance of information technologies and the associated increase in the mobility and liquidity of capital. There have long been cross-border economic processes—flows of capital, labor, goods, raw materials, tour...