Oral microbes represent one of the most well studied microbial communities owing to the fact that they are a fundamental part of human development influencing health and disease, an easily accessible human microbiome, a highly structured and remarkably resilient biofilm as well as a model of bacteria-bacteria and bacteria-host interactions. In the last 80 years since oral plaque was first chara...

A wide range of bacterial species are harbored in the oral cavity, with the resulting complex network of interactions between the microbiome and host contributing to physiological as well as pathological conditions at both local and systemic levels. Bacterial communities inhabit the oral cavity as primary niches in a symbiotic manner and form dental biofilm in a stepwise process. However, exces...

The oral cavity is a complex environment. It serves as a portal between the outside and the inside of an organism. It is the primary organ regulating what is or is not allowed to enter the gut as food. It performs the ¢rst line of food selection (by physical feel and chemical taste) and processing (by mechanical and enzymatic breakdown). It also performs the additional functions of speech and e...

Delayed-release dimethyl fumarate (DMF) is an oral therapy for relapsing multiple sclerosis with anti-inflammatory and neuroprotective properties. This 2-period crossover study was conducted to evaluate the potential for drug-drug interaction between DMF (240 mg twice daily) and a combined oral contraceptive (OC; norgestimate 250 μg, ethinyl estradiol 35 μg). Forty-six healthy women were enroll...

BACKGROUND Thrombotic disorders remain a leading cause of death in the Western World. For decades, vitamin K antagonists used in the prevention of this pathology, such as warfarin or sintrom, were the only oral agents available for long-term anticoagulation, in spite of their disadvantages. MATERIAL AND METHODS An electronic database search was carried out on MedLine and The Cochrane Library ...

To compare pharmacokinetics and evaluate drug-drug interactions of the studied drug Miladean® oral dispersible tablets 3 mg + 5 (JSC Valenta Pharm, Russia) reference products Akatinol Memantine 10 film-coated (Merz Pharma GmbH & Co. KGaA, Germany) Melaxen (Unipharm Inc., USA).

Salivary proteomics is an intriguing area of immunobiological interactions. Heat shock proteins are uniquely conserved molecules that maintain high percentage of homology in all species. These proteins mainly act by inducing antiapoptotic and immunoregulatory mechanisms in intraas well as extracellular milieu. They have been proposed to play an important role in saliva by maintenance of microbi...

The occurrence of bi-directional drug interactions between antiepileptic drugs (AEDs) and combined oral contraceptives (OCs) pose potential risks of un-intended pregnancy and as well as seizure deterioration. It is well established that several of the older AEDs (carbamazepine, phenytoin and phenobarbital), are strong inducers of the hepatic cytochrome P450 (CYP) 3A4 enzyme system, and are asso...

In the sea urchin embryo, the animal-vegetal axis is established during oogenesis and the oral-aboral axis is specified sometime after fertilization. The mechanisms by which either of these axes are specified and patterned during embryogenesis are poorly understood. Here, we investigated the role of cellular interactions in the specification of the ectoderm territories and polarization of the e...