Morphine administration during pregnancy causes several behavioral abnormalities in offspring animals. In the present study the effects of maternal morphine consumption on development of neural tube in Wistar rats (250-300 g) were investigated. Female rats (n = 8 were crossed with male rats and pregnant ones were treated with oral morphine (0.01, 0.05 and 0.1 mg/ml of water) until the 10th day ...

In Japan, transdermal fentanyl (Durotep Patch) was launched in March 2002, and it was regarded as making opioid rotation possible. When changing from morphine to transdermal fentanyl, the efficacy ratio of 1:150 is used in Japan as well as in many other countries. However, the ratio of 1:100 is used in Germany. As a result, a dose increase in transdermal fentanyl is often required to control pa...

objective: previous studies, focusing on the effects of abused drugs, have used mice or rats as the main animal models; the present study tries to introduce a simple animal model. for this propose, we investigated the effects of oral morphine consumption by parents on the development of larvae, pupae and imago in drosophila melanogaster (d. melanogaster). materials and methods: in this experime...

Opioids are widely used as analgesics for oral mucositis in allogeneic hematopoietic cell transplantation (allo-HCT). Their main adverse events are nausea, vomiting, constipation, psychological symptoms, and respiratory depression. In our institute, continuous intravenous morphine was generally used until 2007, followed by intravenous fentanyl as the first-line agent because of its potential fe...

Background: Morphine and lidocaine are known to influence the perception of pain. The present study sought to determine the influence of local administration of morphine on lidocaine-induced analgesia in morphine non-dependent (MND), morphine dependent (MD) and morphine withdrawal (MW) animals. Methods: Adult male Wistar rats were divided into four groups: Control, MND, MD and MW rats. Lidocai...

Statins, 3-hydroxy-3-methylglutaryl co-enzyme A (HMG-CoA) reductase inhibitors, are widely used in the management of different diseases beyond their primary indication for lowering cholesterol. Previous studies have demonstrated the neuroprotective effects of simvastatin in different animal models. In the present study, we examined the effects of simvastatin (30, 60, 100 and 300mg/kg, p.o.) on ...

PURPOSE There are several reports about effects of Salvia spp. on CNS. The present experiment is undertaken to study effect of S. limbata, S. hypoleuca and S. macrosiphon on withdrawal syndrome in mice. METHODS Antinociceptive activities of aerial parts of Salvia spp. is investigated using hot plate method. In addition, the effect of its aerial parts on morphine dependence is investigated in ...

Background: An unwavering availability of opioids is crucial for effective pain and palliative care managing opioid dependence. This study aims to the pattern morphine consumption use safety protocols prescribing in a tertiary cancer hospital India. Patients methods: We studied medical pharmacy records retrospectively, investigate oral Morphine distribution from 2008 2020. Results: The number n...