The aim of our study was to assess the efficacy and safety of topical timolol maleate combined with oral propranolol for nasus externus infantile hemangiomas. Between March 2012 and May 2014, propranolol was given orally to 17 infants with proliferating hemangiomas in a dose of 1.0-1.5 mg/kg/day in our department and dipped topically a small amount of 0.5% timolol maleate eye drops with medical...

Coherence between the bioelectric activity of sensorimotor cortex and contralateral muscles can be observed around 20 Hz. By contrast, physiological tremor has a dominant frequency around 10 Hz. Although tremor has multiple sources, it is partly central in origin, reflecting a component of motoneuron discharge at this frequency. The motoneuron response to ~20 Hz descending input could be altere...

Ten patients with cirrhosis and protal hypertension received an initial 20 mg oral test dose of propranolol and subsequently 160 mg of a slow release preparation, orally, each day for seven days. Protein binding, serial plasma propranolol concentrations and effects on heart rate were studied. Protein binding was slightly reduced (mean 85%, range 78.9-88.1%) compared with four normals (mean 87.9...

INTRODUCTION AND OBJECTIVES Infantile hemangiomas (IH) are a frequent vascular tumor. In recent years, propranolol has emerged as an alternative in the treatment of IH. The objective of the present study was to evaluate the effectiveness of propranolol for the treatment of IH. MATERIALS AND METHODS Patients with IH requiring treatment were included. Cardiologic evaluation was made to every pa...

We studied the effects of oral propranolol administered in 2 low dose schedules (5 or 20 mg 8 hourly) and for a short term (30 to 36 hours) on heart rate, plasma renin activity, and arterial pressure, both at rest and after an isoprenaline challenge (8 mg i.v. over 2 min) in 6 normal subjects. Resting heart rate, plasma renin activity, and systolic pressure all fell significantly after the 5 mg...

In 11 asthmatic subjects the relative magnitude and the site of airway bronchoconstriction were compared after the oral administration of 40 mg of propranolol and 2.5 mg of pindolol and the magnitude and site of bronchodilation produced by 0.5 mg subcutaneous terbutaline were tested after pretreatment with propranolol and pindolol. Specific airway conductance (sGaw) and peak expiratory flow rat...

buccoadhesive drug delivery systems have distinct advantages in comparison with oral administration. plant exudates like gum or mucilage are being studied for their use as pharmaceutical adjuvant. the aim of this study is to evaluate the properties of the plantago major seed mucilage as a mucoadhesive agent and propranolol hydrochloride is chosen as a model drug. mucoadhesive tablets of propran...