introduction: leukoplakia is the most common precancerous lesion of the oral mucosa and may range microscopically form benign hyperkeratosis to invasive squamous cell carcinoma. p53 is a tumor suppressor protein; whereas, proliferative cell nuclear antigen (pcna) is a proliferative marker. the aim of this study was to evaluate the immunohistochemical expressions of p53 and pcna in oral leukopla...

Title of Dissertation: INVESTIGATION OF INTERCELLULAR ADHESION MOLECULE-1 TARGETED DRUG TRANSPORT ACROSS THE GASTROINTESTINAL EPITHELIUM Rasa Ghaffarian, Doctor of Philosophy, 2015 Dissertation directed by: Associate Professor, Silvia Muro Fischell Department of Bioengineering & Institute for Bioscience and Biotechnology Research Contrary to systemic injection of therapeutics, oral formulations...

Zein was investigated for use as an oral-drug delivery system by loading prednisolone into zein microparticles using coacervation. To investigate the adaptability of this method to other drugs, zein microparticles were loaded with hydrocortisone, which is structurally related to prednisolone; or mesalazine, which is structurally different having a smaller LogP and ionizable functional groups. I...

Nano particle formulations, especially protein based formulations are great drug delivery systems for a targeted and sustained drug release. The Specificity lies with the receptor-ligand binding mechanism adopted by them. Metformin hydrochloride (MET) is a widely used biguanide oral antidiabetic agent, against Type II diabetes. In its free form, it suffers some shortcomings like poor oral bioav...

Diabetes mellitus (diabetes) is suffered by more than 180 million people and is responsible for approximately 2.9 million deaths each year. This mortality rate is expected to increase by 50 % in the next decade. Due to the inconvenience of the traditional treatment of diabetes by subcutaneous administration of insulin injection, various attempts are made in the production, purification, formula...

Porcine epidemic diarrhea virus (PEDV), an enteric coronavirus, is the causative agent of porcine epidemic diarrhea (PED) that damages intestinal epithelial cells and results in severe diarrhea and dehydration in neonatal suckling pigs with up to 100% mortality. The oral vaccine route is reported as a promising approach for inducing protective immunity against PEDV invasion. Furthermore, dendri...

background : there is disagreement on the effect of diabetes on oral hygiene. the purpose of this study was to assess the oral health and hygiene status of type 1 diabetic patient. methods : in this case control study, periodontal health and hygiene of 80 children and adolescents (5–18 yr of age) with type 1 diabetes mellitus referred to pediatric endocrine clinic of besat hospital hamadan iran...

To answer challenge of targeted and controlled drug release in oral delivery various materials were studied by different methods. In the present paper, controlled metal based drug (Pd(II) complex) release manner of β‑Lactoglobulin (β-LG) nanoparticles was investigated using mathematical drug release model in order to design and production of a new oral drug delivery system for gastrointestinal ...

The oral route is the preferential route of drug delivery in humans. However, effective delivery through the gastrointestinal tract is often hampered by the low permeability of the intestinal epithelium. One possibility to overcome this problem is the encapsulation of drugs inside nanoparticulate systems, containing targeting moieties with cell invasive properties. The bioinvasive features of t...