chloroma or granulocytic sarcoma (gs) is a malignant neoplasm of myeloid lineage that occur in a variety of anatomic sites other than the bone marrow including soft tissue, bone, lymph node, nasal fossa, skin and sometime in the orbit. in the subconjunctiva it is rarely reported. a 4-year-old girl with a history of treated acute myelogenous leukemia was referred to farabi eye hospital, tehran, ...

background ewing’s sarcoma family is a group of small round cells tumors. the aim of this study is to evaluate clinicopathologic characteristics and outcome of ewing’s sarcoma in children and adolescents in yazd, iran. materials and methods all patients under 19 years with documented pathology of ewing’s sarcoma family tumor who referred to shahid ramazanzadeh radiotherapy center between 2002 t...

An outpatient regimen of oral high-dose methotrexate was studied in 14 patients with solid tumours over 12 months. Detailed pharmacokinetic analysis in five patients showed high oral bioavailability (mean +/- SE of mean 87.6 +/- 1.5%), indicating that with this regimen oral methotrexate was well absorbed and the first-pass effect low. Oral administration resulted in peak plasma methotrexate con...