3718 Cell Cycle Volume 11 Issue 20 Of the hallmarks of cancer,1 the process of invasion and metastases is arguably the least well-understood and therefore least drugable. Invasion through the extracellular matrix is arguably the critical distinction between carcinoma in situ and carcinoma with metastatic potential. Efforts to understand targetable mechanisms of cancer invasiveness are sorely ne...

In vitro models of traumatic brain injury (TBI) are indispensable to explore the effects of mechanotrauma on neurological injury cascades and injury thresholds. This study characterizes a novel in vitro model of neural shear injury, which for the first time subjects organotypic cultures to inertia-driven shear strain. In this model, organotypic cultures preserved a high level of biological hete...

: This review discusses the utility and limitations of model gut systems in accurately modelling mucosa digestive tract from both an anatomical functional perspective, with a particular focus on oesophagus upper tract, what this means for effective vitro oesophageal pathology. Disorders include heartburn, dysphagia, eosinophilic oesophagitis, achalasia, spasm gastroesophageal reflux disease. 3D...

Tumor progression is controlled by signals from cellular and extra-cellular microenvironment including stromal cells and the extracellular matrix. Consequently, three-dimensional in vitro tumor models are essential to study the interaction of tumor cells with their microenvironment appropriately in a biologically relevant manner. We have previously used organotypic co-cultures to analyze the ma...

BACKGROUND Minocycline, a second-generation tetracycline antibiotic, exhibits anti-inflammatory and neuroprotective effects in various experimental models of neurological diseases, such as stroke, Alzheimer's disease, amyotrophic lateral sclerosis and spinal cord injury. However, conflicting results have prompted a debate regarding the beneficial effects of minocycline. METHODS In this study,...