The present study explored the interaction between histaminergic and opioidergic systems at the level of the hippocampus in modulation of orofacial pain by intra-hippocampal microinjections of histamine, pyrilamine (an antagonist of histamine H(1) receptors), ranitidine (an antagonist of histamine H(2) receptors), morphine (an opioid receptor agonist) and naloxone (an opioid receptor antagonist...

Diagnosis and treatment of temporomandibular disorders (TMDs) have been within the domain of dentistry for many decades. However, the field of TMDs and other causes of orofacial pain is undergoing a radical change, primarily because of an explosion of knowledge about pain management in general. As a result, etiological theories about TMDs are evolving toward a biopsychosocial medical model from...

Orofacial pain conditions are often very debilitating to the patient and difficult to treat. While clinical interest is high, the proportion of studies performed in the orofacial region in laboratory animals is relatively low, compared with other body regions. This is partly due to difficulties in testing freely moving animals and therefore lack of reliable testing methods. Here we present a co...

OBJECTIVE The aim of this study was to evaluate the effect of topical treatment with pregabalin and diclofenac on neuropathic orofacial pain induced by infraorbital nerve injury in the rat. STUDY DESIGN Sixty-four Sprague-Dawley rats underwent infraorbital nerve injury. Seven days after surgery, pain was verified and the rats randomly assigned to topical or systemic treatment with pregabalin ...

Pain is the primary reason patients visit a physician or dentist, and the diagnosis and management of pain in the face, mouth and jaws have been integral components of dental practice since dentistry became a widely recognized profession in the 19th century. Epidemiologic studies reveal that a large proportion of the population in many countries currently suffers from temporomandibular disorder...

BACKGROUND AND OBJECTIVES: The glossopharyngeal neuralgia is a neuropathy considered rare that manifests itself in the IX cranial nerve distribution characterized by an electric shock-like pain, often associated with hyperalgesia and allodynia. The etiology may be related to vascular changes, brain tumor, or even idiopathic. The aim of this study was to report a case of glossopharyngeal neuralg...