UNLABELLED Thiazide diuretics are effective antihypertensive medications shown to reduce the risk of cardiovascular events and stroke. Despite being the preferred choice for uncomplicated essential hypertension, thiazide diuretics continue to be underutilized. METHODS Uncomplicated essential hypertension patients taking a single antihypertensive medication were evaluated upon enrollment, diag...

Thiazide diuretics are widely used for the management of hypertension. In recent years, it has been actively debated that there is interchangeability of thiazide-type diuretics hydrochlorothiazide and thiazide-like diuretics including indapamide and chlorthalidone for the treatment of hypertension. With the purpose of seeking out the best thiazide diuretic for clinicians, we summarized the exis...

The sixth report of the Joint National Committee on the prevention, detection, evaluation, and treatment of high blood pressure (JNC-VI) states that diuretics or beta-blockers (BB) should be the drugs of choice when initiating treatment of uncomplicated hypertension.1 In contrast, the report of the World Health Organization and the International Society of Hypertension (WHOISH) does not express...

Since the turn of the 21st century, gene knockout mice have been created for all major urea transporters that are expressed in the kidney: the collecting duct urea transporters UT-A1 and UT-A3, the descending thin limb isoform UT-A2, and the descending vasa recta isoform UT-B. This article discusses the new insights that the results from studies in these mice have produced in the understanding ...