UNLABELLED DamID is a powerful technique for identifying regions of the genome bound by a DNA-binding (or DNA-associated) protein. Currently, no method exists for automatically processing next-generation sequencing DamID (DamID-seq) data, and the use of DamID-seq datasets with normalization based on read-counts alone can lead to high background and the loss of bound signal. DamID-seq thus prese...

Zirkonium is a set of Mac OSX software tools to aid the composition of spatial music; the software allows composers to design multiple spatial trajectories with an intuitive GUI and facilitates arranging them in time. According to the provided trajectory information, the actual audio signals can then be rendered in real-time for 2D or 3D loudspeaker systems. For developing the latest version of...

Background: Tooth extraction is surgical treatment with clinical manifestation alveolar bone resorption of 11-63% which potentially fails dental implant treatment. Socket preservation regeneration to minimize morphological changes in post-extraction using graft. Anti-inflammatory biomaterial needed modulate inflammatory cascade the lesion. Anthocyanin ternatin a flavonoid derived from butterfly...

BACKGROUND Osteoporosis and other bone degenerative diseases are among the most challenging non-communicable diseases to treat. Previous works relate bone loss due to osteoporosis with oxidative stress generated by free radicals and inflammatory cytokines. Alternative therapy to hormone replacement has been an area of interest to researchers for almost three decades due to hormone therapy-assoc...

Mangiferin is a xanthone glucoside, which possesses antioxidant, antiviral, antitumor and anti-inflammatory functions, and is associated with gene regulation. However, it remains unknown whether mangiferin protects osteoblasts, such as the MC3T3-E1 cell line, against glucocorticoid-induced damage. In the present study, MC3T3-E1 cells were treated with dexamethasone (Dex), which is a well-known ...

INTRODUCTION Ankylosing spondylitis (AS) is characterized by abnormal bone formation in the spine and the sacroiliac joints. In vitro assays demonstrate that carbonic anhydrase I (CA1) promotes calcium precipitation. This study investigated the function of CA1 for bio-mineralization and determined if common polymorphisms in the CA1 gene might contribute to AS risk. METHODS Calcification was i...

Magnesium is the fourth most abundant element in human body with a wide battery of functions maintenance normal cell homeostasis. In bone, this incorporates hydroxyapatite structure and it takes part mineral metabolism regulates osteoclast functions. study, sol-gel materials increasing concentrations MgCl 2 (0.5, 1, 1.5%) were synthesized applied onto Ti surfaces as coatings. The first physicoc...