Ovarian cryopreservation and grafting has resulted in successful ovulation, pregnancy, and live-born animals including mice and sheep (1, 2). The procedure is currently being offered to humans as a new method of assisted reproduction. However, its value frequently has been questioned because of a potential to reintroduce the malignant cells, viral infections, and induction of immune responses a...

t d t d b SUMMARY 1. Physicians should inform cancer patients about options for fertility preservation and future reproduction prior to treatment. 2. The only established methods of fertility preservation are sperm cryopreservation in men and embryo cryopreservation in women. 3. Experimental procedures such as oocyte or ovarian tissue cryopreservation should be offered only in a research settin...

t d t d b SUMMARY 1. Physicians should inform cancer patients about options for fertility preservation and future reproduction prior to treatment. 2. The only established methods of fertility preservation are sperm cryopreservation in men and embryo cryopreservation in women. 3. Experimental procedures such as oocyte or ovarian tissue cryopreservation should be offered only in a research settin...

Whole ovary cryopreservation and transplantation has been proposed as a method for preserving long-term ovarian function. This work reports ovarian function 6years post transplantation of frozen-thawed whole sheep ovaries. Three 9-month-old Assaf sheep underwent unilateral oophorectomy to provide organs for the experiments. After perfusing with cold University of Wisconsin solution supplemented...

The risk of developing premature ovarian failure and azoospermia is a major concern in long-term survivors treated for Hodgkin's lymphoma. Alkylating chemotherapy containing procarbazine and/or cyclophosphamide causes prolonged azoospermia in 90-100% of men and premature ovarian failure in 5-25% of women under the age of 30. The risk of infertility increases with the cumulative dose of alkylati...

Aggressive chemotherapy/radiotherapy and bone marrow transplantation can cure >90% of girls and young women affected by disorders requiring such treatment. However, the ovaries are very sensitive to cytotoxic drugs, especially to alkylating agents. Several options are currently available to preserve fertility in cancer patients. The present review reports the results of 60 orthotopic reimplanta...