Bilateral ovariectomy was performed in 11 mares and unilateral ovariectomy in 2 mares. The horses were standing and sedated for surgery. After appropriate preparation a laparoscope was inserted into the abdomen through the paralumbar fossa and the ovary was identified and anaesthetised with local anaesthetic via a custom-built needle. The ovary was then withdrawn from the abdomen through a sepa...

Purpose: To investigate the effect of Notopterygium incisum Ting ex H.T. Chang extract (NICE) on ovariectomy-induced osteoporosis in rats.
 Methods: Female Sprague-Dawley rats were randomly assigned to a normal group (control) and five ovariectomy (OVX) subgroups: OVX with vehicle (OVX), positive control drug alendronate sodium tablets (1.8 mg/kg/week), varying NICE doses (45, 90, or 180 m...

Background/Aim: Sulphur mineral water is widely used in the treatment of musculoskeletal diseases. Hydrogen sulphide an important regulator bone metabolism and its application osteoporosis intensively researched. The aim this study was to analyse biochemical histological effects H2S containing "Mlječanica" spring on ovariectomy-induced experimental rats. Methods: In experiment a 14-week-old Wis...

Osteoporosis is a systemic skeletal disease and there is a close relationship between the sympathetic nervous system (SNS) and bone metabolism. Leptin has been shown to regulate bone formation and bone resorption via the SNS. However, the effect of SNS on leptin signaling has not been clearly understood. In the present study, we studied the effect of propranolol on ovariectomy-induced osteoporo...

Background: Polycystic ovary syndrome (PCOS) is an endocrine disturbance that causes primary anovulation that result in infertility. There are more symptoms accompanying this syndrome: acne, hirsutism, obesity, irregular menstrual cycle and many others. This syndrome can be more or less successfully treated but in 10-15% of cases it is resistant to any kind of treatment used in nowadays practic...

Allosteric Activation of Transglutaminase 2 (TGM2) serves as a cellular target small molecule forskolin to promote osteoblast differentiation and ameliorate ovariectomy-induced osteoporosis. Forskolin binds TGM2 on previously undisclosed allosteric site activate by inducing an “open” conformation, thereby improving mitochondrial energy metabolism for osteoporosis treatment. More details can be ...

For evaluation of factors modifying renal carcinogenesis, several groups of 6-week-old C57BL X C3H Fj mice of both sexes were exposed once to 60 or 121)ng ot ethylnitrosourea per g of body weight. This treatment was preceded in some groups by partial hepatectomy and/or ovariectomy. Animals were killed at 90 weeks of age, and the incidence of renal tumors was evaluated. Ethylnitrosourea induced ...