1. Plasma oxalate has been measured by a radioisotopic method applicable to all concentrations of plasma oxalate and renal function, and also by an enzymatic method which was only applicable to raised concentrations of plasma oxalate. 2. Where the two methods could be applied simultaneously, the agreement between them was good. 3. Plasma oxalate was 86% ultrafiltrable at concentrations of up to...

Oxalic acid undergoes enzymic transformation along diverse channels in cell-free preparations from micro-organisms and plants. In Collyvia veltepes oxalate undergoes a simple decarboxylation (Shimazono, 1955; Shimazono & Hayaishi, 1957), whereas in other micro-organisms the decarboxylation is preceded by the formation of the CoA derivative of oxalate (Jakoby, Ohmura & Hayaishi, 1956; Kimura, Ka...

Developing soybean seeds accumulate very large amounts of both soluble oxalate and insoluble crystalline calcium (Ca) oxalate. Use of two methods of detection for the determination of total, soluble, and insoluble oxalate revealed that at +16 d postfertilization, the seeds were 24% dry mass of oxalate, and three-fourths of this oxalate (18%) was bound Ca oxalate. During later seed development, ...

The present research evaluated the anti urolithic potential of Cyperus rotundus tubers extract using in silico, vitro and vivo techniques. In silicostudy was performed constituents pathological protein oxalate oxidase (PDB Id: 2ETE). vitrostudy, nucleation aggregation assay involved for assessment ethanol tuber (50-3000 µg/ml).In studies that rotundusethanolic (100, 200 400 mg/kg B.wt.) wastrea...

BACKGROUND The enteric excretion of oxalate has been established in rats with chronic renal failure induced by 5/6 nephrectomy [Hatch et al.: Regulatory aspects of oxalate secretion in enteric oxalate elimination. JASN 1999;10:S324] and this response is mediated by angiotensin II receptor activation. However, the renal and intestinal handling of oxalate has not been evaluated for other common m...

For mammals, oxalate enters the body through the diet or is endogenously produced by the liver; it is removed by microbial oxalate metabolism in the gut and/or excretion in feces or urine. Deficiencies in any one of the these pathways can lead to complications, such as calcium oxalate urinary stones. While considerable research has been conducted on individual oxalate-degrading bacterial isolat...

This study evaluated the ability of the lactic acid bacteria (LAB) component of canine and feline feces to degrade oxalate in vitro. Oxalate degradation by individual canine-origin LAB was also evaluated. The effects of various prebiotics on in vitro oxalate degradation by selected oxalate-degrading canine LAB was also evaluated. Canine fecal samples reduced oxalate levels by 78 +/- 12.2% (mean...

Mice deficient for the apical membrane oxalate transporter SLC26A6 develop hyperoxalemia, hyperoxaluria, and calcium oxalate stones due to a defect in intestinal oxalate secretion. However, the nature of the basolateral membrane oxalate transport process that operates in series with SLC26A6 to mediate active oxalate secretion in the intestine remains unknown. Sulfate anion transporter-1 (Sat1 o...

NEPHROLITHIASIS (kidney stones) has a lifetime prevalence in the developed world of 5% in females, and up to 12% in males, with recurrence in 50% of cases. Normal human urine is supersaturated with respect to the calcium oxalate ion pair, and roughly two thirds of kidney stones are composed predominantly of calcium oxalate. Oxalate input derives from dietary oxalate absorbed across the gut muco...

Oxalate urolithiasis (nephrolithiasis) is the most frequent type of kidney stone disease. Epidemiological research has shown that urolithiasis is approximately twice as common in men as in women, but the underlying mechanism of this sex-related prevalence is unclear. Oxalate in the organism partially originate from food (exogenous oxalate) and largely as a metabolic end-product from numerous pr...