Acute cyanide (CN) poisoning leads to deterioration of body functions and often results in death. It can be accidental, suicidal, at times homicidal. Since the historical period, CN has been cause for several deaths, including fire accidents, industrial waste leakage, suicides famous persons, planned massacres. Several sources lead poisonings, such as smoke from fire, mining other industries, n...

An organism’s survival depends on its ability to adapt stress. Mitochondria are the cellular integrators of environmental stressors that ultimately translate their responses at organismal level, and thus central process whereby organisms respective environments. produce molecular energy via oxidative phosphorylation then allows cells biosynthetically respond changes in environment. Reactive oxy...

Sertraline, a selective serotonin reuptake inhibitor, has been used for the treatment of depression. Although it is generally considered safe, cases of sertraline-associated liver injury have been documented; however, the possible mechanism of sertraline-associated hepatotoxicity is entirely unknown. Here, we report that mitochondrial impairment may play an important role in liver injury induce...

TOBIN, RICHARD B., CARL R. MACKERER, AND MYRON A. ~EHLMAN. PH ejf’ects on oxidative phosphorylation of rat liver mitochondria. Am. J. Physiol. 223(l) : 83-88. 1972.-Respiration and oxidative phosphorylation of rat liver mitochondria were studied polarographically as functions of the pH of the incubation medium. Oxidation of pyruvate in the presence of ADP (state 3) and succinate, pyruvate, a-ke...

During late gestation, villi extend into the intestinal lumen to dramatically increase the surface area of the intestinal epithelium, preparing the gut for the neonatal diet. Incomplete development of the intestine is the most common gastrointestinal complication in neonates, but the causes are unclear. We provide evidence in mice that Yin Yang 1 (Yy1) is crucial for intestinal villus developme...

The effects of cortisone treatment on oxygen consumption, oxidative phosphorylation, and fine structure of rat liver mitochondria have been studied. Male rats weighing 125 g were treated for 6 days with 5 mg of cortisone acetate or isotonic saline. On the 7th day, sections of liver were excised and processed for light and electron microscopy. Mitochondrial respiration and oxidative phosphorylat...

Mitochondrial Diseases (MD) are disorders of function in cellular oxidative phosphorylation caused by diverse nuclear DNA and mtDNA mutations and seen in 1/5,000 births. The purpose of this study was to examine relationships across medical indices, biochemical measures, and neurobehavioral functioning in children with MD. Findings from Western Blot, Native Gels, High Resolution Respirometry, an...

Background: Successful IVF process is limited by factors such as oocyte quality. Oocyte quality can be defined as its abilities to be fertilized, mature and give rise to normal offspring and it is dependent on nuclear maturation and cytoplasm maturation. Damage to mitochondrial DNA (mtDNA) has been described in oocytes in IVF failure women that decrease cytoplasmic quality because Mitochondria ...

Increased aerobic metabolism during exercise is a potential source of oxidative stress. In muscle, mitochondria are one important source of reactive intermediates that include superoxide (O2*-), hydrogen peroxide (H2O2), and possibly hydroxyl radical (HO*). The recent discovery that mitochondria may generate nitric oxide (NO*) also has implications for oxidant production and mitochondrial funct...