The voltage-gated sodium channel Na(V)1.8 is expressed exclusively in nociceptive sensory neurons and plays an important role in pain pathways. Na(V)1.8 cannot be functionally expressed in non-neuronal cells even in the presence of beta-subunits. We have previously identified Pdzd2, a multi PDZ-domain protein, as a potential interactor for Na(V)1.8. Here we report that Pdzd2 binds directly to t...

Hox genes are crucial determinants of cell fates and of body morphology of animals; mutations affecting these genes result in abnormal patterns of programmed cell death. How Hox genes regulate programmed cell death is an important and poorly understood aspect of normal development. In the nematode C. elegans, the Hox gene mab-5 is required for the programmed cell deaths of two lineally related ...

The conventional Lorenz-Mie formalism is extended to the case for a coated sphere embedded in an absorbing medium. The apparent and inherent scattering cross sections of a particle, derived from the far field and near field, respectively, are different if the host medium is absorptive. The effect of absorption within the host medium on the phase-matrix elements associated with polarization depe...

For m = 3, 4, . . . those pm(x) = (m − 2)x(x − 1)/2 + x with x ∈ Z are called generalized m-gonal numbers. Recently the second author studied for what values of positive integers a, b, c the sum ap5 + bp5 + cp5 is universal over Z (i.e., any n ∈ N = {0, 1, 2, . . . } has the form ap5(x) + bp5(y) + cp5(z) with x, y, z ∈ Z). In this paper we proved that p5 + bp5 + 3p5 (b = 1, 2, 3, 4, 9) and p5 +...

Acute basophilic leukemia (ABL) is a rare subtype of acute leukemia with clinical features and symptoms related to hyperhistaminemia because of excessive growth of basophils. No known recurrent cytogenetic abnormality is associated with this leukemia. Rare cases of t(X;6)(p11;q23) translocation have been described but these were sporadic. We report here 4 cases of ABL with a t(X;6)(p11;q23) tra...

The helicity amplitudes of the electroexcitation of the Roper resonance on proton are extracted at 1.7 < Q < 4.2 GeV 2 from recent high precision JLab-CLAS cross sections data and longitudinally polarized beam asymmetry for π electroproduction on protons. The analysis is made using two approaches, dispersion relations and unitary isobar model, which give consistent results. It is found that the...