BACKGROUND Apoptosis in human atherosclerotic coronary plaques possibly causes plaque destabilization by contributing to the weakening and breaking down of the fibrous cap. We tested the hypothesis that apoptosis is quantitatively increased in unstable atherosclerotic plaques. METHODS AND RESULTS We analyzed the expression of apoptotic genes such as BAX, CASP1, FAS, FAS L, FOS, MDM2, NFkB2, P...

AIM: To evaluate the multiple biomarkers of colorectal tumor and their potential usage in early diagnosis of colorectal cancers. METHODS: Multiple biomarkers (DNA contents, AgNOR, PCNA, p53, c-erbB-2) in 10 normal colorectal mucosae, 37 colorectal adenomas and 55 colorectal cancers were analyzed quantitatively in the computed processing imaging system. Discrimination patterns were employed to e...

According to the work done in my lab the most significant issues is the average age at which the breast cancer effect the women of east and west, there is a clear difference of 10 years as the average age of eastern women is 50 years and western female gets at 60 years and this difference of 10 year is being carried by the migrant women in the west as well and many studies should this differenc...

OBJECTIVE To quantitate antiapoptotic and proapoptotic gene expression in endometrial cells (ECs) of women with and without endometriosis. DESIGN Determination of transcript abundance (TA) of apoptosis-regulating genes in eutopic and ectopic endometrial cells. SETTING Institute for the Study and Treatment of Endometriosis, Chicago, Illinois, and university-based research laboratories. PAT...

Objective. Non-neoplastic and neoplastic mucosal lesions from orophayngolaryngeal region constitute a major health problem in developing countries. Carcinoma of this region is the commonest neoplasm in male in our country. The study was aimed at testing for the accuracy of cytological diagnosis as well as morphometry analysis and compared with histopathology in order to see whether the correlat...

In this study, proliferating cell nuclear antigen (PCNA) and p53 protein expressions were analyzed in 16 cases of ameloblastoma and 8 cases of adenomatoid odontogenic tumor (AOT). The cases of ameloblastoma consisted of solid type tumors and histologic arrangements of different subtypes were observed. In some specimens, more than one histologic subtype was identified in the same lesion, and eac...

Deletions and/or mutations of p53 are relatively rare and late events in the natural history of B-cell chronic lymphocytic leukemia (B-CLL). However, it is unknown whether p53 signaling is functional in B-CLL and if targeted nongenotoxic activation of the p53 pathway by using nutlin-3, a small molecule inhibitor of the p53/MDM2 interaction, is sufficient to kill B-CLL cells. In vitro treatment ...