Paliperidone palmitate (PP) is a recently introduced long-acting atypical, or second-generation, antipsychotic. Published data on PP are currently limited to controlled trials and case reports. In this observational study, we followed up 200 consecutive patients prescribed PP in normal practice. After 1 year, 65% of patients were still receiving PP. The number of admissions to hospital in the y...

PURPOSE/BACKGROUND The study objective was to compare the impact of being treated by paliperidone palmitate (PP) or risperidone long-acting injection (RLAI) on the length of stay on initial hospitalization, rehospitalization risk, and treatment duration in schizophrenic patients. METHODS We conducted an observational retrospective cohort study in 43 centers in France, including schizophrenic ...

Long-acting injectable antipsychotics constitute a valuable alternative for the treatment of psychotic disorders, mainly schizophrenia. They assure a more stable drug level, improve treatment compliance, and increase the chances for favorable and long-lasting improvement. Additionally, the long-acting second-generation antipsychotics combine the values of long-acting injectable drugs with the v...

The purpose of the study was to increase the dissolution and bioavailability of BCS class II drug, paliperidone by amorphization. The technique that was evaluated for preparing amorphous paliperidone (PAL) was Hot Melt Extrusion (HME). In case of hot melt extrusion process, copovidone was used essentially as a hydrophilic polymer with plasticizers like PEG (6000 and 20000), stearic acid and cet...

INTRODUCTION We conducted an updated systematic review and meta-analysis of randomized controlled trials (RCTs) comparing blonanserin with other antipsychotics (amisulpride, aripiprazole, haloperidol, paliperidone, and risperidone). METHODS Weighted mean difference (WMD), risk ratio, and number needed to harm (NNH) with 95% confidence intervals (95% CIs) were calculated using random-effects m...

PURPOSE The emergence of electronic prescribing devices with clinical decision support systems (CDSS) is able to significantly improve management pharmacological treatments. We developed a web application available on smartphones in order to help clinicians monitor prescription and further propose CDSS. METHOD A web application (www.MEmind.net) was developed to assess patients and collect dat...

BACKGROUND Second-generation antipsychotics (SGAs) represent an advance in the long-term management of schizophrenia. AIMS To review the available evidence concerning SGA long-acting injections (LAIs). METHOD A systematic review of the literature was conducted using PubMed. RESULTS Risperidone long-acting injection was the first licensed SGA-LAI compound and is effective in the long-term ...

Results Antipsychotics are used in 27% of the patients, with a predominancy in the female gender (77.8%), a global average age of 57.9 ± 12.6 years. There is a predominancy of absence of psychiatric background (55.6%) and the absence of previous hospitalisations (66.7%). In 96.3% of the sample there was no toxic abuse. It is observed the following distribution in the use of antipsychotics: quet...