Usha Narayanan,1 Vijayalaxmi Nalavadi,2 Mika Nakamoto,1 David C. Pallas,3,5 Stephanie Ceman,6 Gary J. Bassell,2 and Stephen T. Warren1,3,4 Departments of 1Human Genetics, 2Cell Biology, 3Biochemistry, and 4Pediatrics and 5Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322, and 6Department of Cell and Developmental Biology, University of Illinois, Urbana-Champa...

A new oleanene glucuronide called melilotus-saponin O2 (1) was isolated together with three known ones (soyasaponin I, astragaloside VIII, wistariasaponin D) from the aerial parts of Melilotus officinalis (L.) Pallas (Leguminosae). The structure of 1 was determined to be 3-O-alpha-L-rhamnopyranosyl-(1-->2)-beta-D-xylopyranosyl- (1-->2)-beta-D-glucuronopyranosyl melilotigenin by spectroscopic an...

The emergence of adaptive interfaces [Benyon 1993, Benyon & Murray 1988] provides a satisfactory framework for taking into account users heterogeneity. In adapting to the user’s characteristics, these interfaces could, in principle, minimize training and support costs, as well as improve user’s satisfaction and productiveness. However, so far, there is no general agreement on adaptive interface...

BACKGROUND The ATHENA (A Placebo-Controlled, Double-Blind, Parallel Arm Trial to Assess the Efficacy of Dronedarone 400 mg bid for the Prevention of Cardiovascular Hospitalization or Death from Any Cause in Patients with Atrial Fibrillation/Atrial Flutter) trial demonstrated a significant reduction (26%) in the rate of first cardiovascular (CV) hospitalization in dronedarone-treated patients wi...

AIMS This study aimed to assess safety and cardiovascular outcomes of dronedarone in patients with paroxysmal or persistent atrial fibrillation (AF) with coronary heart disease (CHD). Coronary heart disease is prevalent among AF patients and limits antiarrhythmic drug use because of their potentially life-threatening ventricular proarrhythmic effects. METHODS AND RESULTS This post hoc analysi...

Abstract Chemistry plays a key role in many aspects of astrophysical fluids. Atoms and molecules are agents for heating cooling, determine the ionization fraction, serve as observational tracers, build molecular foundation life. We present implementation chemistry module publicly available magnetohydrodynamic code Athena++ . implement several chemical networks cooling processes suitable simulat...