129 Elevations in serum levels of pancreatic enzymes are usually in the range of 14–80% in intensive care unit (ICU) patients who have no prior pancreatic pathology. 1,2 Although most of these patients do not develop clinical pancreatitis, pancreatic damage associated with elevated pancreatic enzymes is present. It is difficult to assess the clinical symptoms and signs of acute pancre-atitis in...

Aim: The present study investigated the inhibitory effect of methanolic extract of Couroupita guianensis leaves (MCG) on carbohydrate hydrolysing enzymes and glucose uptake in isolated rat hemidiaphragm. Method: The effects of MCG at different concentrations (1.25-10mg) were carried out on carbohydrate hydrolysing enzymes namely porcine pancreatic αamylase, rat intestinal α-glucosidase and sucr...

Abstract In order for the intestinal mucosa to absorb dietary proteins they have be digested into single amino acids or very short peptides of a length not more than four acids. study efficiency digestive endopeptidases digest folded we analyzed several target under different conditions, native proteins, heat denatured and acid treated. The three pancreatic serine proteases, trypsin, chymotryps...

Pancreatic ductal adenocarcinoma (PDAC) is projected to become the second deadliest cancer by 2030, and the overall 5-year survival rate is currently less than 7%. Cancer cells frequently exhibit reprogramming of their metabolic activity. It is increasingly recognized that aberrant de novo lipid synthesis and reprogrammed lipid metabolism are both associated with the development and progression...

The nature and mechanism of the pancreatic exocrine dysfunction in diabetes mellitus were evaluated in vitro using isolated pancreatic acini prepared from streptozotocin-induced diabetic rats. The content of amylase and ribonuclease in diabetic acini was approximately 0.5 and 50% of the normal content, respectively. Further, reduced amounts of both enzymes were secreted by diabetic acini in res...

Thirty-seven pigs were used to evaluate the effects of age and weaning on the level of protease in the gastric mucosa and trypsin, chymotrypsin, amylase and lipase in the pancreas. There was a positive allometry of the pancreas and gastric mucosa associated with age and with weaning to a solid diet. Increases with age in total activity of chymotrypsin, trypsin, amylase and gastric proteases wer...

It is unknown whether nonparallel pancreatic enzyme output occurs under basal conditions in humans. We aimed to determine whether the circadian or wake-sleep cycle influences the relationship among pancreatic enzymes or between pancreatic secretory and jejunal motor activity. Using orojejunal multilumen intubation, we measured enzyme outputs and proximal jejunal motility index during consecutiv...

In considering the use of digestive enzyme supplements, it is not uncommon to question the survivability of unprotected enzymes through the digestive process. Pancreatic enzymes, available as both drugs and dietary supplements, are known to require enteric coating to prevent permanent denaturing by gastric acidity. Fortunately, not all enzymes require these coatings to survive the gastric envir...

Gallstone pancreatitis was first recognized as an entity by Opie in 1901 (1), and since then has generated volumes of literature which have attempted to explain its pathophysiology. Multiple animal experiments and human clinical studies in the past thirty years have led to a better understanding of both macro- and microscopic events which lead to pancreatic inflammation in the setting of a pass...

Pancreatic panniculitis is a rare skin disorder that occurs in 2-3% of pancreatic diseases, mostly associated with acute or chronic pancreatitis. Its pathophysiology is still unclear, but the release of pancreatic enzymes in circulation can be responsible for this disorder. The typical histological features are adipocyte necrosis with neutrophils infiltrate and typical "ghost cells". Its treatm...