نتایج جستجو برای: pantothenate kinase
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PURPOSE The onset of pantothenate kinase-associated neurodegeneration (PKAN) occurs in the first and second decade of life and a pigmentary retinal degeneration is a feature of the disorder. Since the neuro-ophthalmologic and electroretinographic (ERG) features have never been well delineated, we describe them in 16 patients with PKAN. DESIGN Observational case series. METHODS Sixteen patie...
OBJECTIVE Neurodegeneration with brain iron accumulation (NBIA) represents a group of inherited movement disorders characterized by iron accumulation in the basal ganglia. Recent advances have included the identification of new causative genes and highlighted the wide phenotypic variation between and within the specific NBIA subtypes. This study aimed to investigate the current status of NBIA i...
Mutants of Escherichia coli K-12 defective in the pantothenate permease (panF) were isolated and characterized. The panF mutation resulted in the complete loss of pantothenate uptake and of the ability to use extracellular vitamin for growth. The growth phenotypes of panF panD, panF panB, and panF panC double mutants showed that the cytoplasmic membrane was impermeable to external pantothenate....
Basal medium...................... 52.5 58.7 61.1 57.4 58.4 62.6 46.3 60.1 0.05% yeast extract added.......... 73.5 76.7 79.4 80.1 71.3 67.2 78.6 78.5 All vitamins doubled............... 70.1 77.8 75.3 76.1 67.9 68.2 75.1 71.6 Double vitamins plus 0.05% yeast extract .......................... 73.4 76.8 79.4 79.5 71.8 67.6 78.5 78.6 Only the thiamin doubled.......... 55.1 56.2 59.8 59.1 57.8 61...
Although bacteria and eukaryotes share a pathway for coenzyme A (CoA) biosynthesis, we previously clarified that most archaea utilize a distinct pathway for the conversion of pantoate to 4'-phosphopantothenate. Whereas bacteria/eukaryotes use pantothenate synthetase and pantothenate kinase (PanK), the hyperthermophilic archaeon Thermococcus kodakarensis utilizes two novel enzymes: pantoate kina...
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