A 32-year-old woman presented with an 8-month history of verrucous and suppurative skin lesions on the anogenital area. She was diagnosed with human immunodeficiency virus (HIV) infection 18 months before and was receiving antiretroviral therapy thereafter. She underwent excision and experienced recurrence of perineal warts since the age of 28 years. Clinical examination showed oval hyperchromi...

Tumoración dolorosa de rápido crecimiento en la región subungueal del primer dedo de la mano derecha Medical History A 51-year-old man presented with a very painful, rapidly growing tumor in the subungual area of the first digit of the right hand. The lesion had first appeared a month earlier. The patient had sustained a crush injury to the same digit 20 years earlier. Physical examination reve...

The angiogenic cytokine vascular endothelial growth factor (VEGF)-A plays a central role in both wound healing and tumor growth. In the skin, epidermal keratinocytes are a major source of this growth factor. To study the contribution of keratinocyte-derived VEGF-A to these angiogenesis-dependent processes, we generated mice in which this cytokine was inactivated specifically in keratin 5-expres...

Psoriasis is a chronic inflammatory disease of the skin characterized by epidermal hyperplasia, dermal angiogenesis, infiltration of activated T cells, and increased cytokine levels. One of these cytokines, IL-15, triggers inflammatory cell recruitment, angiogenesis, and production of other inflammatory cytokines, including IFN-gamma, TNF-alpha, and IL-17, which are all upregulated in psoriatic...

INTRODUCTION Anti-tumor necrosis factor (anti-TNF) treatments are effective in controlling disease activity in many immune-mediated diseases such as psoriasis and ankylosing spondylitis (AS). Although side effects such as infection and skin reactions are predictable in anti-TNF treatment; susceptibility to psoriasis is considered as a paradoxical side effect. CASE REPORT We report a case of f...

A 77-year-old woman from Guyana presented with a 3-year history of a generalized, pruritic eruption associated with chronic chills, fatigue, generalized malaise, and a 14-kg weight loss over a 9-month period (Figure 1). Her medical history was significant for hypertension and diabetes, and her medications included glucophage, atenolol, and lisinopril. She had no personal or family history of at...

This study was aimed at the histological investigation of the impact of experimental diabetes on the healthy gingiva of rats. Thirty male Wistar rats were used in this study. The animals were randomly divided into two groups (n = 15) prior to the experiment. Group 1 experimental diabetes was created by streptozotocin injection in 15 rats. Group 2 comprised the control group (15 rats). On the 7t...

Although(,) vascular remodeling is a hallmark of many chronic inflammatory disorders such as rheumatoid arthritis, inflammatory bowel disease, and psoriasis, anti-vascular strategies to treat these conditions have received little attention to date. We investigated the anti-inflammatory activity of systemic blockade of VEGF-A by the inhibitory monoclonal antibody G6-31, employing a therapeutic t...

We describe an 88-year-old woman with various lesions in the right submammary region that had remained stable for more than 40 years. She reported rapid growth and ulceration of one of the lesions in the past year. The examination showed a firm tumor of diameter 7 cm below the right breast. The surface of the tumor was keratotic at the periphery and ulcerated in the middle with foul-smelling se...

Population dynamics of chamois (genus Rupicapra, subfamily Caprinae) can be influenced by infectious diseases epizootics, of which sarcoptic mange is probably the most severe in the Alpine chamois (Rupicapra rupicapra rupicapra). In this study, skin lesions and cellular inflammatory infiltrates were characterized in 44 Alpine chamois affected by sarcoptic mange. Dermal cellular responses were e...