BACKGROUND Personalized medicine (PM) aims to tailor disease prevention, diagnosis, and treatment to individuals on the basis of their genes, lifestyle and environments. Patient and interest organizations (PIOs) may potentially play an important role in the realization of PM. This paper investigates the views and perspectives on PM of a variety of PIOs. METHODS Semi-structured telephone inter...

Epidemiological studies have linked ambient particulate matter (PM) levels to an increased incidence of adverse cardiovascular events. Yet little is definitively known about the mechanisms accounting for the cardiovascular events associated with PM exposure. The goal of this study was to determine the effects of ultrafine (<0.1 microm) PM exposure on ischemia-reperfusion (I/R) injury. ICR mice ...

Described here is progress in an experimental program to develop a 21 cell multicell trap for the accumulation and storage of ~ 10 positrons. The basic architecture is an arrangement of multiple Penning-Malmberg (PM) trapped plasmas (i.e., cells) arranged in parallel in a common vacuum system and magnetic field. Experiments are described that are intended to address several key issues, includin...

Upwelling off the east coast of Peninsular Malaysia (PM) was detected from recent cruise data collected during the southwest monsoon. Thermocline lifting was observed at 104 ̊E from a number of parallel transects. To confirm the presence of upwelling, satellite remote sensing data were used, and numerical model experiments were conducted. A cooler sea-surface temperature along the coast was spot...

Early transmitral flow (MiF) patterns depend strongly on the rate of fall of measured left ventricular pressure (Pm) determined by both the active decay of pressure (Pa) due to myocardial relaxation and the increase in pressure due to stretch of passive elements during filling (Pp). This study was designed to uncouple passive forces from deactivation in order to reveal the instantaneous rate an...