BACKGROUND Recent studies have identified common genetic variants associated with TSH, free T4 and thyroid peroxidase antibodies, but it is unclear whether these differ between patients with Hashimoto's disease and Graves' disease. OBJECTIVE To examine whether 11 common genetic variants differ between Graves' disease and Hashimoto's disease. PATIENTS AND MEASUREMENTS We genotyped 11 common ...

An algorithm for solving the Cauchy problem a three-dimensional difference equation with constant coefficients by given of and initial data in parallelepiped. The is based on Apanovich Leirnartas theorems characterizing well-posedness problems uses computer algebra methods to achieve computational efficiency.The implemented Matlab.

A 46-year-old womanwith hypothyroid Graves' disease (EMOsyndrome) is reported. The patient had bilateral exophthalmos, conjunctival chemosis, periorbital edema and limitation of lateral gaze. Laboratory examination revealed the presence of primary hypothyroidism with positive thyroid-stimulating hormone (TSH) binding inhibitory immunoglobulin and thyroid stimulation antibody. These fiindings in...

OBJECTIVE To find out a correlation between the single nucleotide polymorphisms in cluster of differentiation 28 and cluster of differentiation 40 genes with Graves' disease, if any. METHODS This case-control study was conducted at the Multan Institute of Nuclear Medicine and Radiotherapy, Multan, Pakistan, and comprised blood samples of Graves' disease patients and controls. Various risk fac...

Graves' disease, the main cause of hyperthyroidism in the pediatric age group, is very rare in children younger than 4 years old but can seriously interfere with growth and development if not recognized and treated. Here we report a case of a 3-year-old girl with Graves' disease who presented with goiter, exophthalmos, heat intolerance, and hyperactivity. At her first visit, her serum concentra...

© Copyright National Graves’ Disease Foundation, Inc., 1990–2000. All rights reserved. The exact cause and pathophysiology of the soft tissue changes in the eyelids and orbit in Graves’ disease continue to remain unknown. The management of these changes, particularly in the acute stage, presents a very frustrating problem to the doctor and the patient. This area is filled with controversy as il...

Thyroid ophthalmopathy, or Graves’ ophthalmopathy, is the most common cause of exophthalmos in adults. Graves first described thyroid disease with associated ophthalmopathy in 1835. To date, the pathogenesis of thyroid ophthalmopathy remains speculative, as reflected by the numerous names by which it is described such as dysthyroid ophthalmopathy or thyroid eye disease, thyroid orbitopathy, eut...

The use of multidetector computed tomography (MDCT) is an integral part of contemporary diagnostics of Graves‘ orbitopathy. The aim of this study was to assess proptosis measurement by MDCT and to compare it to the current standard, Hertel exophthalmometry. A cross-sectional study was conducted at the Clinical Centre of Serbia and included 91 patients (19 male and 72 female) with verified Grave...

BACKGROUND Graves' disease is an autoimmune thyroid disorder characterized by hyperthyroidism, and patients exhibit thyroid-stimulating hormone receptor antibody. The major methods of measuring circulating thyroid-stimulating hormone receptor antibody include the thyroid-stimulating hormone-binding inhibitory immunoglobulin assays. Although the diagnostic accuracy of these assays has been impro...

Analytical solutions are presented for Fraunhofer diffraction by the following nonspherical particles: rectangular parallelepiped, hexagonal cylinder, spheroid, and threeaxis ellipsoid. Using these solutions, numerical results for the diffracted intensity of these particles in specific orientations and 3-D random orientation for an ensemble of particles of the same size are presented and discus...