There is a high demand for engineering thermostable enzymes in some industries; especially in paper industries to use environmental friendly enzymes instead of toxic chlorine chemicals. Hence, understanding protein attributes involved in enzyme thermostability is important. Herein, the most important protein features contributing to enzyme thermostability was searched by using data mining algor...

Anorectal melanoma is an uncommon and aggressive mucosal melanocytic malignancy. Due to its rarity, the pre-operative diagnosis remains difficult. The first symptoms are non-specific such as anal bleeding, anal mass or pain. Although anorectal melanoma carries a poor prognosis; optimal therapeutics strategies are unclear. Surgical resection remains the mainstay of treatment. The optimal surgica...

Abstract. MAP estimators and HPD credible sets are often criticized in the literature because of paradoxical behaviour due to a lack of invariance under reparametrization. In this paper, we propose a new version of MAP estimators and HPD credible sets that avoid this undesirable feature. Moreover, in the special case of non-informative prior, the new MAP estimators coincide with the invariant f...

Prediction accuracy of pharmacokinetic parameters is often assessed using prediction fold error, i.e., being within 2-, 3-, or n-fold of observed values. However, published studies disagree on which fold error represents an accurate prediction. In addition, "observed data" from only one clinical study are often used as the gold standard for in vitro to in vivo extrapolation (IVIVE) studies, des...

I propose a theory of the passive that combines aspects of the principles and parameters analysis (no specific rules, no downward movement) and Chomsky’s (1957) Syntactic Structures analysis (the arguments in the passive are generated in the same positions as they are in the active).

A large number of molecular mechanisms exist to ensure the continued function of perturbed cells. Here we explore a range of mechanisms of molecular robustness. A theory of robustness is proposed in which mechanisms are classified into those that purge damage, and those that buffer damage. The strategy upon which a system settles, is a function of the cost of purgation, and thereby a function o...

Thas paper presents the desagn of a fuzzy usage parameter controller (FUPC) for ATM (asynchronous transfer mode) networks The usage parameter control (UPC) as here based on a dual leaky bucket (DLB) mechanasm, wath parameters of token generatzon rate and token pool saze. In FUPC, we further e m p l o y parameters of token-change rate and anterarnval tame of zncomzng cells as znput languastac va...

? This article aims to analyse the importance of the Wikipedia articles in different languages (English, French, Russian, Polish) and the impact of the importance on the quality of articles. Based on the analysis of literature and our own experience we collected measures related to articles, specifying various aspects of quality that will be used to build the models of articles importance. For ...