BACKGROUND Mortality from invasive meningococcal disease (IMD) has remained stable over the last thirty years and it is unclear whether pre-hospital antibiotherapy actually produces a decrease in this mortality. Our aim was to examine whether pre-hospital oral antibiotherapy reduces mortality from IMD, adjusting for indication bias. METHODS A retrospective analysis was made of clinical report...

Objective: To compare the clinical efficacy and cost effectiveness of early intravenous to oral switch Amoxicillin/Clavulanate and parenteral Ceftriaxone in treatment of hospitalized patients with community acquired pneumonia (CAP). Design: Open, randomized, parallel group comparative study. Setting: Department of Medicine at Services Hospital, Lahore Patients and Methods: Fifty patients with c...

Aim: To report a rare case of endogenous panophthalmitis in a diabetic with chronic kidney disease undergoing haemodialysis. Methods: A 54 year old male diabetic and hypertensive with chronic kidney disease (CKD) on maintenance haemodialysis through a tunnelled internal jugular vein (IJV) catheter with IJV catheter infection was being treated with parenteral Imipenam. He complained of sudden pa...

RADIOACTIVITY DISTRIBUTION WAS DETERMINED IN SERUM AND MILK OF LACTATING EWES AFTER PARENTERAL ADMINISTRATION OF FIVE LABELED ANTIBIOTICS: (14)C-benzylpenicillin G, (3)H-dihydrostreptomycin, (3)H-tetracycline, (14)C-chloramphenicol, and (14)C-spiramycin. Antibiotic levels were measured simultaneously by microbiological assay. Radiochemical and microbiological assay procedures presented similar ...

BACKGROUND Candida albicans has been the most common cause of fungal bloodstream infections (BSIs) in intensive care units (ICUs); however, infections due to non-albicans Candida species have been increasing in prevalence. We examined factors associated with BSIs due to non-albicans Candida species, compared with C. albicans BSIs, in an ICU patient population. METHODS For our case-comparator ...

Abstract Background Limb gangrene in neonates is an extremely rare clinical problem and very few cases have been recorded up to now. The clinical findings were mild involvement of skin to full necrosis and gangrene of the involved regions. Unfortunately, in most cases the etiology cannot be established. However, a variety of etiological causes may account for this condition. Case Presentatio...

Sepsis commonly occurs in severe post-burn patients, often resulting in death. We aimed to evaluate the influence of early enteral feeding on outcomes in patients with extensive burns, including infection incidence, healing and mortality. We retrospectively reviewed 60 patients with extensive burns, 35 who had received early enteral nutrition and 25 who had received parenteral nutrition. Averag...

OBJECTIVE To provide evidence-based recommendations on the treatment of nervous system Lyme disease and post-Lyme syndrome. Three questions were addressed: 1) Which antimicrobial agents are effective? 2) Are different regimens preferred for different manifestations of nervous system Lyme disease? 3) What duration of therapy is needed? METHODS The authors analyzed published studies (1983-2003)...

Acute rhinosinusitis is a widespread pathology faced by both outpatient doctors and otorhinolaryngologists in hospitals. At the same time, only understanding of principles for diagnosing various forms sinusitis, particular, criteria bacterial provides adequate treatment decisions. Antibacterial therapy plays key role patients with acute sinusitis. Additionally, there an increasing frequency ant...

Rhodococcus equi is an unusual cause of infection in humans. Infection in immunocompetent patients is extremely rare-only 19 cases in immunocompetent hosts have been reported. Localized infections represent nearly 50% of reported cases. Pulmonary infections account for only 42% of infections in immunocompetent hosts, compared with 84% of infections in immunocompromised hosts. The mortality rate...