Although physiological function of alpha-synuclein is not yet clearly understood, accumulating evidence strongly suggests it plays a crucial role in the pathogenesis of Parkinson disease. Pathologically, alpha-synuclein is a major component of Lewy bodies, which is the pathological hallmark of Parkinson disease. Alpha-synuclein pathology is observed in the brainstem nuclei, including the dorsal...

introduction: parkinson’s disease is one of the most disabling diseases which by electrode implantation and stimulation of subthalamic nucleus (stn), much progress has been made in the treatment of drug resistant patient. this new method of neurosurgery may have some neuropsychological side effects on the patients. the main aim of this study is to evaluate the effects of this kind of treatment ...

b a c k ground: several studies have indicated that executive dysfunction is the main neuropsychological feature of parkinson’s disease (pd). the frontal assessment battery (fab) is a short tool for the assessment of executive functions. p u r p o s e : the aim of this study was to determine the relationship between persian version of fab scores and age, education, mini-mental state examination...

parkinson's disease is a degenerative disorder of the central nervous system. the motor symptoms of parkinson's disease result from the death of dopamine-generating cells in the substantia nigra, a region of the midbrain the cause of this cell death is unknown. homocysteine (hcy) is a non-protein amino acid. it is a homologue of the amino acid cysteine. the elevated levels of homocysteine in pl...

whole body vibration (wbv) is a contemporary treatment modality that holds promise as an exercise training method in health–compromised individuals. a growing number of studies on individuals with parkinson disease are examining whether wbv improves balance and functional mobility. however, interpreting wbv studies is challenging since there is variability in the manner in which wbv interventio...

since its first description of botulism toxicity in 1820s, specific formulations of botulinum neurotoxin (bont) have been introduced with different clinical benefits. however, there is increasing number of adverse events reported to food and drug administration. this report presents the case of 62-year-old woman with parkinson’s disease who received bont injections to treat painful spasticity i...