BACKGROUND/AIM Selective serotonin reuptake inhibitors are the most commonly chosen antidepressants in patients with Parkinson's disease (PD). The aim of our study was to assess the influence of fluoxetine (Flu) on motor functions in patients with PD. METHODS In this prospective, controlled, open-label study, 18 patients with PD and mild depression [(10 < or = Hamilton Rating Scale for Depres...

Deep brain stimulation (DBS) has been widely used to control motor symptoms and improve quality of life in patients with Parkinsons disease (PD). Recently, DBS in the subthalamic nucleus (STN) has become the preferred target for patients with mixed motor symptoms. Despite resultant motor and quality of life improvements, the procedure has been associated with cognitive decline, mainly in langua...

Astrocytes, which have various important functions, have previously been associated with Parkinsons disease (PD), particularly in 1-methyl-4-phenylpyridinium (MPP+) and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) models of PD. MPP+ is the toxic metabolite of MPTP and is generated by the enzymatic activity of monoamine oxidase B, which is predominantly located in astrocytes. MPP+ acts as...

Unsupervised clustering algorithms have been used in many applications to group the data based on relevant similarity metrics. K-Means clustering is one of the most widely used clustering techniques owing to its simplicity. Many improvements and extensions have been proposed for this algorithm in view to improve its performance. Out of the various dimensions that have been explored in this rega...

Neural prostheses have already a long history and yet the cochlear implant remains the only success story about a longterm sensory function restoration. On the other hand, neural implants for deep brain stimulation are gaining acceptance for variety of disorders including Parkinsons disease and obsessive-compulsive disorder. It is anticipated that the progress in the field has been hampered by ...

Hyperkinetic movement disorders affect people in a wide range of ages, from children with autism motor stereotypies to the elderly with Parkinsonian tremor. Unwanted normal and or abnormal movement of the arms significantly affects the quality of life for both young and old. Physicians who manage chronic neurological movement diseases (e.g., Parkinsons) tend to make many decisions based on subj...

Parkinson's is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Being a neurological disease, spinal anaesthesia is often avoided in Parkinson's. Yet, in Parkinsons' patients, general anaesthesia may mask neurolog...

A number of brain diseases, e.g. movement disorders such as Parkinsons disease, are characterized by abnormal neuronal synchronization. Within the last years permanent high-frequency (HF) deep brain stimulation became the standard therapy for medically refractory movement disorders. To overcome limitations of standard HF deep brain stimulation, we use a model based approach. To this end, we mak...

CONTACT US 1. http://www.parkinsons.org.uk/content/what-parkinsons. Accessed August 2015. 2. Cancela J, Arredondo MT, Hurtado O. Guidelines for the economic analysis of a telemetic platform for Parkinson's disease monitoring. BIBE. 2013: page 1-4. IEEE. 3. Wood et al. Incidence and predication of falls in Parkinson's disease: a prospective multidisciplinary study. J Neurol Neurosurg Psychiatry....

Deep brain stimulation (DBS) is an established therapy for the treatment of movement disorders, and has shown promising results for the treatment of a wide range of other neurological disorders. However, little is known about the mechanism of action of DBS or the volume of brain tissue affected by stimulation. We have developed methods that use anatomical and diffusion tensor MRI (DTI) data to ...