The coronavirus disease 2019 (COVID-19) pandemic stimulated both the scientific community and healthcare companies to undertake an unprecedented effort with aim of understanding molecular mechanisms severe acute respiratory syndrome 2 (SARS-CoV-2) infection developing effective therapeutic solutions. peculiar immune response triggered by this virus, which seems last only few months, led a searc...

I n resource-limited settings, there is a high risk of mother-to-child-transmission (MTCT) of HIV-1. The rate of MTCT without specifi c intervention and with an extended time of breast-feeding is about 35%– 40% [1], a fi gure that results in the infection of about 750,000 children every year worldwide [2]. A single dose of nevirapine can reduce the rate of MTCT by 42%, but it selects for drug-r...

Good personal hygiene is one of the most important measures for control of hepatitis infection. Hepatitis is transmitted by close contact with an infected person or nonhuman primate, exposure to infected food or water, transfusion of infected blood, dialysis, or contact with hepatitis-containing laboratory specimens. Each of these situations necessitates certain precautions to avoid contaminati...

We have used the delayed-type hypersensitivity (DTH) response to SRBC or tuberculin to examine the role of the murine type 3 complement receptor in T lymphocyte-dependent inflammatory recruitment. Intravenous injection of 5C6, a CR3-specific rat mAb known to impair myelomonocytic adhesion, divided the DTH to SRBC in actively immunized mice into two phases. The early phase, which lasted 24 h, wa...

Studies of immunity to Pseudomonas aeruginosa have indicated that a variety of potential immunogens can elicit protection in animal models, utilizing both antibody- and cell-mediated immune effectors for protection. To attempt to optimize delivery of multiple protective antigens and elicit a broad range of immune effectors, we produced an aroA deletion mutant of the P. aeruginosa serogroup O2/O...

Either active immunization with trehalose-6, 6'-dimycolate (cord factor)-methylated bovine serum albumin complex or passive transfer of rabbit anti-cord factor serum induced in mice an enhanced resistance against infection with virulent human Mycobacterium tuberculosis. This suggests that the anti-cord factor antibody exerts an infection-protecting effect by neutralizing the toxic action of cor...