Game developers are often faced with very demanding requirements on huge numbers of agents moving naturally through increasingly large and detailed virtual worlds. With the advent of multi-core architectures, new approaches to accelerate expensive pathfinding operations are worth being investigated. Traditional single-processor pathfinding strategies, such as A and its derivatives, have been lo...

Searching for relationships between Linked Data resources is typically interpreted as a pathfinding problem: looking for chains of intermediary nodes (hops) forming the connection or bridge between these resources in a single dataset or across multiple datasets. In many cases centralizing all needed linked data in a certain (specialized) repository or index to be able to run the algorithm is no...

Injured neurons intrinsically adapt to and partially overcome inhibitory proteoglycan expression in the central nervous system by upregulating integrin expression. It remains unclear however, to what extent varying proteoglycan concentrations influence the strength of this response, how rapidly neurons adapt to proteoglycans, and how pathfinding dynamics are altered over time as integrin expres...

foxP2, a forkhead-domain transcription factor, is critical for speech and language development in humans, but its role in the establishment of CNS connectivity is unclear. While in vitro studies have identified axon guidance molecules as targets of foxP2 regulation, and cell culture assays suggest a role for foxP2 in neurite outgrowth, in vivo studies have been lacking regarding a role for foxP...

Olfactory sensory neurons (OSNs) expressing a given odorant receptor project their axons to specific glomeruli, creating a topographic odor map in the olfactory bulb (OB). The mechanisms underlying axonal pathfinding of OSNs to their precise targets are not fully understood. Here, we demonstrate that Robo2/Slit signaling functions to guide nascent olfactory axons to the OB primordium in zebrafi...

Game developers are often faced with very demanding requirements on huge numbers of agents moving naturally through increasingly large and detailed virtual worlds. With the advent of multi-core architectures, new approaches to accelerate expensive pathfinding operations are worth being investigated. Traditional single-processor pathfinding strategies, such as A* and its derivatives, have been l...