The interest to rare diseases has increased in the recent decades. Legislation seeks facilitate patients’ access innovative and effective treatment define incentives for pharmaceutical biotechnology companies develop new medicines diseases.The current review presents knowledge adopted solutions field of discusses future issues unmet needs that should be resolved affected patients their families...

after the boom of pharmacological research during the 1950s, mainly as a result of the screening technique, the identification of active molecules, their reshaping by means of pharmaco-chemical drug design, and the creation of extremely efficacious and successful medicines, the pharmaceutical world sought a new source of inspiration. such biota as the tropical forest, a quantity of plants credi...