Human serum albumin (HSA) is the most abundant protein in the blood plasma. Drug binding to HSA is crucial to study the absorption, distribution, metabolism, efficiency and bioavailability of drug molecules. In this study, isothermal titration calorimetry and molecular dynamics simulation of HSA and its complex with indometacin (IM) were performed to investigate thermodynamics parameters and th...

Current oral medications for type 2 diabetes target a single main physiological mechanism. They either activate or inhibit receptors to enhance insulin sensitivity, increase secretion, glucose absorption, production. In advanced stages, combination therapy may be required because of the limited efficacy single-target drugs; however, are becoming more costly, and there is also risk developing co...

Weed management is the major biological constraint in paddy (Oryza sativa L.) producing areas. Predominantly, barnyard grass (Echinochloa crus-galli) a rice-mimicking weed that causes 57% of yield loss rice production. Conventionally, herbicides are site-specific inhibitors often used to suppress E. crus-galli growth. Acetyl-CoA carboxylase (ACCase) an important target for developing novel with...