Many international efforts have been spent to eliminate and/or reduce the emissions and discharges of a wide range of pollutants that have persisted in the environment as well as living organisms [1]. These pollutants are known as a persistent organic pollutants (POPs). Contamination from POPs is a pervasive global problem that urgently demands a global solution [2]. These chemicals include org...

Dietary and tissue residue-based toxicity reference values (TRVs) were derived for mink from the published results of studies in which mink were exposed to polychlorinated dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), biphenyls (PCBs), or related compounds. Because the primary mechanism of toxic action at the least concentration for these compounds is related to activation of the aryl hydro...

1. Patandin S, Dagnelie PC, Mulder PGH, Op de Coul E, van der Veen JE, Weisgias-Kuperus N, Sauer PJJ. Dietary exposure to polychlorinated biphenyls and dioxins from infancy until adulthood: a comparison between breast-feeding, toddler and long-term exposure. Environ Health Perspect 107:45-51 (1999). 2. Duarte-Davidson R, Jones KC. Polychlorinated biphenyls (PCBs) in the UK population: estimated...

BACKGROUND Endometriosis is a common gynecologic disease characterized by the ectopic growth of endometrial tissue. In industrialized countries, it affects approximately 10% of women of reproductive age. Its etiology is unclear, but a multifactorial origin is considered to be most plausible. Environmental organochlorinated persistent pollutants, in particular dioxins and polychlorinated bipheny...

Model compound studies which were previously done for impurities and environmental residues of chlorophenols and for wastes of chlorination processes were extended to the impurities and pyrolysis products of polychlorinated biphenyls (PCBs). Model compounds were commercial products or synthesized and their structures proven by spectroscopic methods. These models were used as analytical referenc...

Studies involving endocrine effects in humans and experimental animals resulting from the exposure to dioxin-like (non-ortho-substituted PCBs, PCDDs/PCDFs) and nondioxin-like (PCBs, OC pesticides) compounds (DLCs and NDLCs) were presented. A variety of reproductive and hormonal parameters, including androgen status, sexual differentiation, and thyroid functionality, were discussed. As in utero ...