Polycystic ovary syndrome (PCOS) is characterized by hormonal and metabolic abnormalities and is thought to increase a risk for cardiovascular diseases. In this study we use speckle tracking echocardiography (STE) to evaluate left ventricular (LV) dysfunction in the early period of the disease. We enrolled 31 patients with PCOS and 32 healthy volunteers as a control group. The participants' age...

background: polycystic ovary syndrome (pcos) causes an increased risk of metabolic cardiovascular syndrome. also, cystatin c serum levels are associated with the risk of cardiovascular events in metabolic syndrome patients. objective: to investigate the relationship between cystatin c in pcos patients. materials and methods: 35 women with pcos were compared to 35 women with healthy matched age ...

Background: Anti-mullerian hormone (AMH) levels may represent the ovarian follicular pool and could be a useful marker of ovarian reserve. The clinical application of AMH measurement has been proposed in the prediction of quantitative and qualitative aspects in assisted reproductive technologies. Objective: This study aimed to assess the relationship between the serum levels of AMH and results ...

BACKGROUND Insulin resistance has an important role in pathophysiology of polycystic ovarian syndrome (PCOS). Yet there are certain controversies regarding the presence of insulin resistance in non-obese patients. OBJECTIVE The aim was to compare the insulin resistance and various endocrine and metabolic abnormalities in obese and non-obese PCOS women. MATERIALS AND METHODS In this cross-se...

BACKGROUND Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder in women. The developmental competence of oocytes and embryos in PCOS patients is reduced to a certain extent (comparing to non-PCOS patients, the high quality embryo rate was decreased by 16% from the data of our centre) during the in vitro fertilization (IVF) process. Cross-talk between the oocyte and cum...

BACKGROUND 5α-reductase activity might be important during the development of polycystic ovary syndrome (PCOS). However, the changes of 5α-reductase activity in PCOS subjects and the relationship between 5α-reductase activity and body mass index (BMI), insulin resistance (IR) remain largely unknown. METHODS We performed a meta-analysis to examine 5α-reductase activity in women with PCOS; expl...

BACKGROUND Polycystic ovary syndrome (PCOS) is a common female endocrinopathy of unclear origin characterized by hyperandrogenism, oligo-/anovulation, and ovarian cysts. Women with PCOS frequently display overweight, insulin resistance, and systemic low-grade inflammation. We hypothesized that endotoxemia resulting from a leaky gut is associated with inflammation, insulin resistance, fat accumu...

Polycystic ovary syndrome (PCOS) is a common endocrine condition in women of reproductive age, which is associated with a range of metabolic implications. Data concerning metabolic features of patients with polycystic ovarian morphology (POM) without any other PCOS diagnostic criteria (nonPCOS-POM) are limited. In the present study, metabolic profile of 46 women with nonPCOS-POM was investigate...

CYP19 encodes aromatase, a key enzyme essential for estrogen biosynthesis. Single nucleotide polymorphism (SNP) rs2470152 in CYP19 is associated with serum estradiol (E2) level and the E2/T (estradiol/testosterone) ratio. A case‑control study including 661 individuals [364 polycystic ovary syndrome (PCOS) patients and 297 controls] was conducted t...

BACKGROUND The aim of this study was to determine the relevance of apelin and insulin resistance (IR) with polycystic ovary syndrome (PCOS) and to assess the possible therapeutic effect of the combined therapy of drospirenone-ethinylestradiol (DRSP-EE) combined with metformin. MATERIAL AND METHODS Sixty-three PCOS patients and 40 non-PCOS infertile patients were recruited. The fasting serum l...