n engl j med 361;23 nejm.org december 3, 2009 2261 This Journal feature begins with a case vignette that includes a therapeutic recommendation. A discussion of the clinical problem and the mechanism of benefit of this form of therapy follows. Major clinical studies, the clinical use of this therapy, and potential adverse effects are reviewed. Relevant formal guidelines, if they exist, are prese...

Joel A. Krauser‡ and F. Peter Guengerich§ From the Department of Biochemistry and Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146 Running title: Isotope Effects in P450 3A4 Testosterone Oxidation Address correspondence to: Prof. F. Peter Guengerich, Department of Biochemistry, Vanderbilt University School of Medicine, 638 Robinson Resear...

In this thesis high resolution soft x-ray measurements from the Alcator C-Mod plasma edge are presented for a variety of different plasma conditions. These measurements provide radial profiles of the soft x-ray emissivity with 1.5 mm resolution or better, and temporal resolution down to 12 μs. These profiles show a distinct and very narrow pedestal shape in H-mode, indicative of the H-mode tran...

Abstract We present PEdestal Neural Network (PENN) as a machine learning model for tokamak pedestal predictions. Here, the is trained using EUROfusion JET database to predict electron temperature and density from set of global engineering plasma parameters. Results show that PENN makes accurate predictions on test database, with R 2 = 0.93 temperature, 0.91 density. To demonstrate applicability...

Our impressive sensitivity to vernier offsets as compared to resolution acuity has long inspired vision researchers to study the phenomena in great detail. In this study we use the test-pedestal framework to compare resolution and vernier acuity. In these experiments the test stimulus is the same for both tasks, only the pedestals differ. When thresholds are expressed in common units of test st...

Abstract The neutral ionisation model proposed by Groebner et al (2002 Phys. Plasmas 9 2134) to determine the plasma density profile in H-mode pedestal, is extended include charge exchange processes pedestal stimulated ideas of Mahdavi (2003 10 3984). then tested against JET data, both a ‘standalone’ version using experimental temperature profiles and also incorporating it Europed EPED. able pr...

Corrugated disparity gratings mounted on depth pedestals were portrayed with random-dot stereograms in order to measure the cyclopean disparity modulation transfer function at various offsets from fixation. We found changes in both sensitivity as well as shape as the magnitude of the pedestal varied. Threshold disparity modulation amplitude curves, plotted as a function of corrugation frequency...

We describe a simple procedure for reducing ADC common noise in modular detectors that does not require additional hardware. A method using detector noise groups should work well for modular particle detectors such as segmented electromagnetic calorimeters, plastic scintillator hodoscopes, cathode strip wire chambers, segmented active targets, and the like. We demonstrate a “second pedestal noi...