OBJECTIVES Familial steroid-sensitive idiopathic nephrotic syndrome is rare, and only approximately 3% of patients have affected siblings. METHODS Herein, we report seven cases of patients with steroid-sensitive idiopathic nephrotic syndrome from three Chinese families. Mutational screening of the Nphs2 gene was performed in all the patients. RESULTS All seven of the familial steroid-sensit...

LANGE, K., WACHSTEIN, M., WASSERMAN, E., ALPTEKIN, F. & SLOBODY, L.B. (1963) The congenital nephrotic syndrome, an immune reaction? American Journal of Diseases of Children, 105, 338. MCDONALD, R., WIGGELINKHUIZEN, J. & KASHULA, R. (1971) The nephrotic syndrome in very young infants. American Journal of Diseases of Children, 122, 507. NORIo, R. (1966) Heredity in the congenital nephrotic syndro...

Abstract Background Nephrotic syndrome is the most common glomerulopathy among children aged 2–18 years and high dose corticosteroids are backbone of its management. Potentially blinding ocular complications often result from nephrotic and/or treatment. We conducted a study to determine prevalence predictors undergoing treatment at Mulago National Referral Hospital. Methods This was cross-secti...

Introduction: Considering that prevoius investigation has included more adult age range, this study aimed to evaluate the agreement between TST and Quantiferon in kidney disease children who are candidate for immunosuppressive medications. Methods: In this cross sectional study, 31 children with renal disease including nephrotic syndrome and renal transplant candidates nominated for immunosu...

Bachground: The aim of this study was to determine of diagnostic value of albumin, anti-thrombin Ш, and fibrinogen factors in the diagnosis of pulmonary embolism compared to lung perfusion scan in patients with nephrotic syndrome referred to Hazrat Ali Asghar hospital of Tehran city (Iran) in 2018-2019.  Methods: This study was cross sectional study that was carried out on 30 patients with nep...

Eight patients with steroid-sensitive nephrotic syndrome which frequently relapsed despite cyclophosphamide treatment were given cyclosporin A (7.5 mg/kg/day to 10 mg/kg/day) for 8 to 12 weeks. Six had minimal change glomerulonephritis and two had focal segmental glomerulonephritis. Cyclosporin A was given to 5 patients when their nephrotic syndrome was in relapse and to 3 patients when the nep...