BACKGROUND Sildenafil, a phosphodiestase type 5 inhibitor, was approved in 2005 for the treatment of pulmonary arterial hypertension (PAH) in adults and is commonly used off-label for pediatric patients. Little is known, however, about sildenafil's side effects in this population. METHODS Single institution, longitudinal survey-based study performed in an outpatient pediatric cardiology clini...

Background: Families are willing to spend their entire lives improving their children due to emotional attachments, which, in turn, increases their exposure to catastrophic health expenditures (CHEs). The present study aimed to estimate the level of exposure to CHEs and its determinants among households with pediatric cancer and oncology disorders. Materials and Methods: This cross-sectional s...

OBJECTIVE To analyze the characteristics of patients who needed a blood transfusion due to epistaxis-caused anemia and to define potential risk factors. DESIGN Retrospective cohort study. SETTING A total cohort of 591 epistaxis patients, prospectively included between March 2007 and April 2008 at the ENT department of the University Hospital of Zurich, was evaluated concerning the need for ...

Background: According to the World Health Organization, one in four people experience a psychiatric disorder throughout his/her life. For centuries, psychiatric patients have been sent to psychiatric hospitals that often stigmatized and located out of the community. Moreover, these patients are stigmatized by the hospital staff because they are not aware of patients’ experience...

There are several distinct tools to identify orthologous gene sequence from homologous gene sequence. Identification of orthologous gene is a major issue, and it is found that orthologous genes are responsible for any genetic disorders. In this paper we are focusing on hematologic disorders and found that orthologous genes are primary actor of haematological disorders. Here we present a novel a...

common variable immunodeficiency (cvid) is a heterogeneous group of disorders, characterized by hypogammaglobulinemia and increased susceptibility to recurrent infections, autoimmunity and malignancies. we have previously shown that some pediatric patients with cvid can respond to meningococcal polysaccharide vaccine. twelve pediatric cases with cvid were re-evaluated to determine whether bacte...

how to cite this article: mohammadi m. clinical neurophysiology in pediatric neurometabolic disorders. iran j child neurol autumn 2014;8:4 (suppl.1):7. pls see pdf.

BACKGROUND The aim of this study was to determine the prevalence and characteristics of rheumatologic manifestations associated with MDS. METHODS Eighty patients with MDS were evaluated by history and physical examination for inflammatory rheumatologic disorders from Jan 2013 to May 2014. Patients who had any signs or symptoms of rheumatologic disorders underwent evaluation by laboratory test...

childhood hepatitis b virus (hbv) infection causes both medical and public health challenges. infants who acquire hbv parentally have up to 90% risk of developing chronic hbv infection. it is now estimated that approximately 10% of worldwide cancers are attributable to viral infection, with the vast majority (>85 %) occurring in the developing world. in this distribution, elevated rate and prev...