A young female with sickle cell disease was treated for biopsy-proven IgA nephropathy. Serum creatinine levels resolved to normal range, but a year later, she presented with oedema, hypertension and acute renal failure. A repeat renal biopsy showed acute-on-chronic thrombotic microangiopathy (TMA). We suggest that circulating microparticles could be a pathophysiological link between sickle cell...

Percutaneous renal biopsy with sonographic guidance is the standard by which renal tissue is sampled. In patients with uncorrectable coagulopathy or other contra-indication, percutaneous biopsy may not be feasible and a transvenous approach is preferred. This method limits the risk of bleeding complications as tissue is obtained endovascularly without transgression of the renal capsule. Arterio...

Renal biopsy is a crucial method in the diagnosis and treatment of acute renal failure of unknown origin, nephrotic syndrome, suspicious interstitial nephritis, and glomerulonephritis as a possible cause of hematuria or proteinuria. Complications occur in 2% to 8% of patients after percutaneous renal biopsy. Complications include gross hematuria, perirenal hematoma, arteriovenous fistula, aneur...

BACKGROUND There has been no published study of biopsy-proven childhood glomerulonephritis in Malaysia. OBJECTIVES To determine the pattern of childhood glomerulonephritis in Johor, Malaysia from a histopathological perspective and the various indications used for renal biopsy in children. MATERIALS AND METHODS Retrospective study was done of all renal biopsies from children under 16 years ...

INTRODUCTION Nonoperative and minimally invasive management techniques for both blunt and penetrating renal trauma have become standard of care over the past decades. We sought to examine the modern epidemiology of renal trauma over the past decade. METHODS A systematic review of PubMed from the past decade was conducted to examine adult and pediatric renal trauma. A total of 605 articles wer...

INTRODUCTION Renal biopsy is the diagnostic modality of choice for the diagnosis of renal parenchymal diseases. The advent of improved imaging techniques and biopsy needles over the years has increased the safety of the procedure and the ability to obtain adequate renal tissue for diagnosis. However, there is paucity of data in this regard from Pakistan. This study shall help in establishing th...