Linear PEI is a cationic polymer commonly used for complexing DNA into nanoparticles for cell-transfection and gene-therapy applications. The polymer has closely-spaced amines with weak-base protonation capacity, and a hydrophobic backbone that is kept unaggregated by intra-chain repulsion. As a result, in solution PEI exhibits multiple buffering mechanisms, and polyelectrolyte states that shif...

Fluorescent organic nanoparticles (FONs) based on carbohydrate polymers were prepared through one-pot hydrothermal treatment of starch in the presence of polyethyleneimine. These FONs (named as PEI-Starch FONs) were characterized by a series of techniques including UV-Vis absorption spectroscopy, fluorescent spectroscopy, Fourier transform infrared spectroscopy, transmission electron microscopy...

Effective induction of an antigen-specific cytotoxic T lymphocyte (CTL) immune response is one of the key goals of cancer immunotherapy. We report the design and fabrication of polyethylenimine (PEI)-coated polymer nanoparticles (NPs) as efficient antigen-delivery carriers that can induce antigen cross-presentation and a strong CTL response. After synthesis of poly(d,l-lactide-co-glycolide) (PL...

Poly(ethylenimine) (PEI) is one of a number of polycations that has been used successfully to transfer genes into living cells. Although PEI shows promise in the field of gene therapy, to date no rigorous proof of mechanism has been published regarding the fate of PEI/DNA administered for transfection. Here we show, by using fluorescent labeling and confocal microscopy, the paths of PEI/DNA com...

A series of polyethyleneimine (PEI) incorporated MIL-101 adsorbents with different PEI loadings were reported for the first time in the present work. Although the surface area and pore volume of MIL-101 decreased significantly after loading PEI, all the resulting composites exhibited dramatically enhanced CO2 adsorption capacity at low pressures. At 100 wt% PEI loading, the CO2 adsorption capac...

It is known that polycations bind to and neutralize glomerular polyanions. Here we examine the effect of the polycation polyethyleneimine (PEI) on glomerular deposition of preformed immune complexes. Bovine serum albumin (BSA)-anti-BSA immune complexes made in 40 times antigen excess were administered following intravenous injection of PEI. Glomerular localization of immune deposits was assesse...

Pancreatic exocrine insufficiency (PEI) frequently occurs secondary to exocrine pancreatic disease (e.g. chronic pancreatitis, cystic fibrosis, cancer) or pancreatic/gastrointestinal surgery, resulting in the maldigestion of nutrients and consequently malnutrition. Pancreatic enzyme replacement therapy (PERT) is the cornerstone of PEI management. Despite its clinical relevance, the diagnosis of...

Several nanocomposites based on Mesoporous Silica Nanoparticles (MSN), aluminum ions, and Polyethyleneimine (PEI) were synthesized by the combination of sol-gel post-synthesis methods. These mainly composed MSN with leading Al PEI species alone or in combination. The Al-MSN, MSN-PEI, Al-MSN/PEI samples characterized using FT-IR, XRD, SEM, EDX, zeta potential, nitrogen physisorption techniques. ...

© 1997 DIGITALSTOCK Feature * This work was supported in parts by NSC 95-2221-E-009-080, NSC94-2752-E-002-006-PAE, and NSC 95-2221-E-002-197, Taiwan, R.O.C. FIRST QUARTER 2007 1531-636X/07/$25.00©2007 IEEE IEEE CIRCUITS AND SYSTEMS MAGAZINE 19 Authorized licensed use limited to: National Chiao Tung University. Downloaded on October 13, 2008 at 06:43 from IEEE Xplore. Restrictions apply. 20 IEEE...

Polyethylenimine (PEI) has been demonstrated to be an effective non‑viral synthetic polymer for efficient gene delivery amongst various cell types in vitro and in vivo. In the present study, 25 kDa linear PEI (L‑PEI) was used to transfer plasmid DNA (pDNA), encoding the enhanced green fluorescent protein reporter gene, into the cultured cochlear epithelium of neonatal mice. The 25 kDa L‑PEI/pDN...