OBJECTIVE Recurrent pelvic organ prolapse (POP) has been attributed to many factors, one of which is lack of vaginal apical support. To assess the role of vaginal apical support and POP, we analyzed a national dataset to compare long-term reoperation rates after prolapse surgery performed with and without apical support. METHODS Public use file data on a 5% random national sample of female Me...

As many of you are aware, on July 13, 2011, the FDA released an “Update on the Safety and Effectiveness of Transvaginal Placement (TVM) of Surgical Mesh for Pelvic Organ Prolapse (POP)”. I am writing this letter in an effort to provide you with a better understanding and a more balanced perspective of the complications that can occur with all forms of vaginal surgery. I am hoping that the follo...

INTRODUCTION Pelvic Organ Prolapse (POP) is a debilitating and common disease that affects women’s quality of life. In a 1997 regional study, 11.1% of all women had the risk of undergoing a POP repair surgery [1]. Most women patients that undergo POP repair are >= 52 years of age and have previously had a hysterectomy. Part of the POP repair problem is that reoperation rates are 30% [2]. This c...

This meta-analysis was conducted to estimate the association between matrix metalloproteinase-1 (MMP-1) expression and pelvic organ prolapse (POP) in women. Relevant studies published before 6 December 2015 were identified by searching PubMed, Ovid, EBSCO, and EMBASE. A total number of five case-control studies, including 182 POP cases and 192 controls, were identified. The results indicated th...

BACKGROUND One in three women who have a prolapse operation will go on to have another operation, though not necessarily in the same compartment. Surgery can result in greater impairment of quality of life than the original prolapse itself (such as the development of new-onset urinary incontinence, or prolapse at a different site). Anterior and posterior prolapse surgery is most common (90 % of...

BACKGROUND To evaluate prolapse-related symptoms, quality of life and sexuality of patients with validated questionnaires before and after surgery for genital prolapse and assess relevance of such an evaluation to select women for surgery. METHODS From November 2009 to April 2010, 16 patients operated on for genital prolapse of grade greater than or equal to 2 (POP-Q classification) were eval...

Pelvic organ prolapse (POP) is characterised by the weakening of the pelvic floor support tissues, and often by subsequent prolapse of the bladder outside the body, i.e. cystocele. The bladder is kept in place by the anterior vaginal wall which consists of a dense extracellular matrix rich in collagen content that is maintained and remodelled by fibroblastic cells, i.e. fibroblasts and myofibro...

Background: Pelvic organ prolapse (POP) is a common reproductive problem affecting more than one-third of women between 20–59 years age, and more than half over 60 years worldwide, negatively their daily physical activities. Aim: To assess determinants symptoms severity pelvic its effect on physical activities among the elderly versus childbearing women. Methodology: A descriptive research ...

BACKGROUND Pelvic floor muscle training can reduce prolapse severity and symptoms in women seeking treatment. We aimed to assess whether this intervention could also be effective in secondary prevention of prolapse and the need for future treatment. METHODS We did this multicentre, parallel-group, randomised controlled trial at three centres in New Zealand and the UK. Women from a longitudina...