Limited efficacy of chemotherapeutic drugs against solid tumors has been attributed to poor drug penetration into tumor tissues. Multicellular layer (MCL) cultures recapitulate barriers to drug penetration and distribution and have been used successfully in the production of clinically relevant data. In the present study, we evaluated the characteristics of paclitaxel (PTX) and 5-fluorouracil (...

This study calculates the financial inclusion index, which includes three dimensions: 1) banking penetration, 2) availability of services, and 3) usage services in 33 provinces Indonesia from 2011-2019. The aims to find empirical evidence on whether affects local tax revenue using Fixed Effects Panel Data Model. results show that Indonesia's average regional index is still a low category. has p...

This study examines linkages between information and communication technology (ICT) dynamics, inequality poverty in order to establish critical masses of that should not be exceeded for ICT dynamics promote gender inclusive education 57 developing countries the period 2012–2016. Poverty is measured with headcount ratio at national lines (% population) while proxied by Gini coefficient, Atkinson...

Using the delta-P(1) approximation to the Boltzmann transport equation we develop analytic solutions for the fluence rate produced by planar (1-D) and Gaussian beam (2-D) irradiation of a homogeneous, turbid, semi-infinite medium. To assess the performance of these solutions we compare the predictions for the fluence rate and two metrics of the optical penetration depth with Monte Carlo simulat...

piroxicam is a non-steroidal anti-inflammatory agent which has an extensive use in rheumatic disorders. since its skin penetration is still a subject for research, the aim of this study was to evaluate the effect of dimethyl sulfoxide on percutaneous penetration of piroxicam gel formulation through skin. in this study, as a model, two types of 0.5% piroxicam new gels, so called red and green ge...

This paper presents a modified form of the Walker-Anderson (W-A) model for analyzing high velocity penetration of an eroding projectile into a concrete target in which the W-A model is improved by incorporating calculations for the plastic flow field of concrete in terms of its compressibility and strain rate sensitivity under severe pressure. With the changes to and calculations of plastic fie...

According to literature, penetration pricing is the dominant pricing strategy for network effect markets. In this paper we show that diffusion of products in a network effect market does not only vary with the set of pricing strategies chosen by competing vendors but also strongly depends on the topological structure of the customers' network. This stresses the inappropriateness of classical "i...

To diagnose the vulnerabilities of target system using a remote penetration test approach needs to avoid the modification of the security configuration of the target network. So the carrier of test codes needs to hide from the IDS filter out of our penetrating test codes. Hence, we proposed a polymorphic carrier which carries encrypted test codes and diversified decrypters, and, the proposed ca...

Africa needs access to the powerful information and communication tools of the internet in order to obtain the resources and efficiency essential for its sustainable development. Unfortunately, in 2014, the data from internetlivestats.com showed only 9.8% of African populations have access to the internet. This relative low internet penetration rate signals a problem that may threaten the econo...