Epilepsy is a neurological disorder characterized by epileptic seizures resulting from neuronal hyperexcitability, which may be related to failures in Na,K-ATPase activity and oxidative stress participation. We conducted this study investigate the impact of antioxidant therapy on stress, activity, seizure factors, mortality rodent seizure/epilepsy models induced pentylenetetrazol (PTZ), pilocar...

The present study is an investigation of anti-epileptic activity of Malachra capitata L. (FamilyMalvaceae) is a wellknown plant which is being used in Indian traditional medicines for treating epilepsy and inflammation. The aqueous extract of Malachra capitata L. (AMC) was subjected to acute toxicity and then screened for anticonvulsant activity on Maximal Electroshock (MES) and Pentylenetetraz...

Repeated administration of pentylenetetrazol (PTZ 30 mg/kg, thrice a week) to mice for 9 weeks and subsequent challenge of the animals with the same dose of PTZ on the last chronic dose produced chemical kindling. The mice showed myoclonic jerks, clonus, Straub’s tail, falling back response and full-blown convulsions. The anticonvulsant profile of chronic administration of BR16A (100 and 500 mg...

In mice, running, clonic and tonic convulsions and lethality were assessed following transcorneal (electroshock) current or convulsant drugs, each administered alone and after cannabidiol (CBD) pretreatment. CBD prevented tonic convulsions caused by a convulsant current (CC) 99.99, and by the convulsant dose (CD) 99.99 values of gamma-aminobutyric acid (GABA) inhibitors, 3-mercaptoproprionic ac...

Vettumaran Gutika produced moderate CNS depressant effect, prolonged pentobarbitone and diazepam induced sleep, produced initial depression followed by stimulation of SMA in mice. It did not effect SCR and CAR in rats, reserpine effects in mice and threshold of tail-flick response in rats. It failed to protect rats and mice aginst Electro, pentylenetetrazol and strychnine induced convulsions an...

Mice deficient in the glial water channel aquaporin-4 (AQP4) show decreased cerebral edema and improved neurological outcome following water intoxication or ischemic challenge. In this report, we tested seizure susceptibility in AQP4 mice. AQP4 mice and wild-type controls were given the chemoconvulsant pentylenetetrazol (PTZ) and monitored for seizure activity. At 40 mg/kg PTZ, all wild-type mi...

Aquaporins are intrinsic membrane proteins involved in water transport in fluid-transporting tissues. In the brain, aquaporin-4 (AQP4) is expressed widely by glial cells, but its function is unclear. Extensive basic and clinical studies indicate that osmolarity affects seizure susceptibility, and in our previous studies we found that AQP4 -/- mice have an elevated seizure threshold in response ...