Computational drug repositioning has been proved as an effective approach to develop new drug uses. However, currently existing strategies strongly rely on drug response gene signatures which scattered in separated or individual experimental data, and resulted in low efficient outputs. So, a fully drug response gene signatures database will be very helpful to these methods. We collected drug re...

Drug repositioning offers an innovative approach to drug discovery with great potential in the field of Alzheimer's Disease and dementia therapeutics. Investigation of licensed compounds enables processing through the drug discovery pipeline in a rapid and cost-effective manner. A growing body of evidence supports the translation of priority compounds to be taken forward to clinical trials, bas...

The tongue repositioning manoeuvre has been demonstrated to lead to a closed rest position of orofacial structures with increased contact of the velum with the tongue and a contact position of the tongue at the hard palate. Within the multifactorial etiology of snoring, the tongue repositioning manoeuvre was used as training method in conjunction with pressure indicating oral shields to reduce ...

Kinesin is the canonical plus-end microtubule motor and has been the focus of intense study since its discovery in 1985. We previously demonstrated a time-dependent inactivation of kinesin in vitro that was fully reversible by the addition of purified casein kinase 2 (CK2) and showed that this inactivation/reactivation pathway was relevant in cells. Here we show that kinesin inactivation result...

OBJECTIVE To evaluate the efficacy of canalith repositioning maneuvers (Semont, Epley, and modified maneuvers) in the treatment of posterior canal benign paroxysmal positional vertigo (BPPV) in comparison to the rate of resolution in the untreated control cohort. DATA SOURCES Source articles were identified by a MEDLINE search of English language sources before 2004 plus manual crosschecks of...

T cells rapidly reposition their centrosome to the center of the immunological synapse (IS) to drive polarized secretion in the direction of the bound target cell. Using an optical trap for spatial and temporal control over target presentation, we show that centrosome repositioning in Jurkat T cells exhibited kinetically distinct polarization and docking phases and required calcium flux and sig...

Histone octamers show a heat-induced mobility along DNA. Recent theoretical studies have established two mechanisms that are qualitatively and quantitatively compatible with in vitro experiments on nucleosome sliding: octamer repositioning through one-base-pair twist defects and through ten-base-pair bulge defects. A recent experiment demonstrated that the repositioning is strongly suppressed i...

percutaneous nephrolithotomy (pnl) is commonly used to treat patients with complex renal calculi. placing a nephrostomy tube is the last step after completing pnl. significant early postoperative discomfort after percutaneous procedure is usually secondary to nephrostomy tubes. the goal of this study is to evaluate the safety of tubeless pnl. a total of 45 patients with mean age of 46.6 years e...

cyproterone acetate (ca) has been loaded to liposome by solvent evaporation and thin film formation technique. the effects of some formulation variables such as temperature of organic solvent evaporation, rotary evaporator speed, volume of organic solvent, volume of balloon and temperature of hydrating buffer has been evaluated. the data showed that bigger balloon with higher surface area has b...

[Purpose] This study was performed to determine the difference in thoracic repositioning sense in young people with and without thoracic flexion syndrome (TFS) in target positions of half extension. [Subjects] People with TFS (n = 15; 7 men and 8 women) and people without TFS (n = 15; 7 men and 8 women) were recruited from three universities. Subjects were guided into a sitting extension target...