Eleven unrestorable primary molars with interradicular radiolucencies were extracted. The granulation tissue was curretted from the sockets and examined using immunofluorescence for the immunoglobulins IgG, lgA, and IgM, and the third component of complement. The results demonstrated the presence of IgG in 100%, C3 in 80%, Ig~ in 54.5%, and IgM in 18.1% of the lesions. In an attempt to describe...

This study was undertaken to investigate the distribution of mast cells (MCs) and the expression of transforming growth factor-β (TGF-β) on tryptase positive MCs in different types of human periapical diseases. Periapical tissues of 78 participates were used in this study, including healthy control (n=28), periapical cyst (n=25), and periapical granuloma (n=25). The tissue samples were fixed in...

Cone beam computed tomography (CBCT) has been specifically designed to produce undistorted three-dimensional information of the maxillofacial skeleton, including the teeth and their surrounding tissues with a significantly lower effective radiation dose compared with conventional computed tomography (CT). Periapical disease may be detected sooner using CBCT compared with periapical views and th...

Conventional nonsurgical endodontic treatment has a high degree of clinical success, but in certain cases surgical intervention becomes necessary. This is the case report of a patient presenting with bilaterally separate periapical lesions in the maxillary anterior region. One lesion was managed by periapical surgery using a novel and safe method of separating the soft tissue mass of the periap...

Apical periodontitis is an inflammatory disorder of periradicular tissues caused by aetiological agents of endodontic origin. The subject has been reviewed by Nair. (1)(2) They are believed to result from inflammatory processes in the periapical tissues associated with bacterial infection and necrosis of the dental pulp in carious teeth. As a consequence of these processes and the inability of ...

The success of root canal treatment is based on total elimination of root canal content, thorough cleaning, shaping and obturation of root canal system. Calcium hydroxide is recommended as intra-canal medicament because of its antibacterial properties, tissue dissolving ability, inhibition of tooth resorption and indication of tissue repair by hard tissue formation. Here we present a series of ...

Objectives: To assess and compare five diagnostic imaging methods used in the identification of periapical diseases, of different diameters, mechanically simulated. Methods: The sample of the present study consisted of 12 dried human mandibles. Digital panoramic radiography, conventional and digital periapical radiography (charged couple device and photo-stimulable phosphor plate), and high-res...

UNLABELLED Previous studies demonstrate that the balance between pro- and anti-inflammatory mediators determines the stable or progressive nature of periapical granulomas by modulating the balance of the osteoclastogenic factor RANKL and its antagonist OPG. However, the cytokine networks operating in the development of periapical lesions are quite more complex than what the simple pro- versus a...