UNLABELLED Simvastatin is a hypocholesterolemic agent presumed to cause peripheral neuropathy. We arranged an experimental design which focuses on the effect of simvastatin on peripheral nerves and neural regeneration. Sciatic nerve injury was performed at midthigh region of male wistar rats either by clamp compression or fine cut. Electrophysiological and electron microscopical studies were ca...

There are conflicting reports as to whether malignant peripheral nerve sheath tumor (MPNST) patients with neurofibromatosis type 1 (NF1) have worse prognosis than non-NF1 MPNST patients. Large clinical studies to address this problem are lacking due to the rareness of MPNST. We have performed meta-analyses testing the effect of NF1 status on MPNST survival based on publications from the last 50...

The genetic mechanisms involved in the transformation from a benign neurofibroma to a malignant sarcoma in patients with neurofibromatosis-type-1- (NF1-)associated or sporadic malignant peripheral nerve sheath tumors (MPNSTs) remain unclear. It is hypothesized that many genetic changes are involved in transformation. Recently, it has been shown that both phosphatase and tensin homolog (PTEN) an...

A rare case of caruncular neurofibroma in a patient who did not have neurofibromatosis. To remember peripheral nerve sheath tumours in the differential diagnosis of caruncular lesions. Excisional biopsy proved to be adequate treatment in our case.

Classically, the different subtypes of the peripheral nerve sheets tumors display typical morphological features which differentiate them from the other nervous tumors. Either schwannoma or neurofibroma have characteristic histological and immunohistochemical features. We present a case of peripheral nerve sheets hybrid tumor which have had histological and immunohistochemical features of neuro...

INTRODUCTION Ancient schwannoma is a rare tumor of the peripheral nerve sheath. As degenerative properties are defined histologically, it can be wrongly interpreted as malignant. CASE PRESENTATION The case presented here is of a giant ancient schwannoma with a pelvic retroperitoneal location, which was mimicking an adnexal mass. CONCLUSION In the rarely seen cases in the retroperitoneum, it...

A 50-year-old man presented with a left-sided neck mass. Clinical examination revealed a large fluctuant 7 cm x 7 cm mass in the left posterior triangle. Magnetic resonance imaging (MRI) revealed an encapsulated soft tissue lesion. He underwent exploration of the neck and a 14 cm by 8 cm mass enfolding the accessory nerve was identified and completely excised. Histological examination of the su...

Schwannomas are peripheral nerve sheath benign tumors which arise from the schwann cells. These neoplasms most frequently seen in 3 to 6 decade of life and affecting limbs followed by head neck region. Oropharyngeal vallecular involvement schwannomas is extremely rarely reported previous literature. We report a case 25 year old male with lesion vallecula was subsequently diagnosed as on histopa...

Neurofibromas are benign peripheral nerve sheath tumors seen arising both sporadically and in patients with neurofibromatosis syndromes. Commonly they of three types: localized, diffuse or plexiform. Pigmented neurofibromas very rare, accounting to <1% all reported. We present a case 64 year old woman Neurofibromatosis 1, large swelling on the right thigh. The mass was grossly pigmented micr...

palisaded encapsulated (solitary circumscribed) neuromas (pens) are relatively common intraoral neurogenic tumors, which occur most frequently on the hard palate. herein, we describe the clinicopathological characteristics of a palisaded encapsulated neuroma of the tongue. this tumor was an exophytic sessile mass measuring 0.3× 0.4 cm with rubbery consistency on the anterior one-third of the do...