The absorption of orally administered drugs requires their movement across the intestinal epithelial barrier. Poor intestinal permeability leads to limited absorption. Generally, if a compound achieves a 90% or greater oral absorption, it is considered highly permeable (for example, propranolol or metoprolol). Drugs that display 50% or less oral absorption are considered poorly permeable (for e...

Group theoretic analysis is performed to get a new Lie group of transformations for non-linear differential systems constructed against mass and heat transfer in the thermally magnetized non-Newtonian fluid flow towards heated stretched porous surface. The energy equation used with additional effects, namely sink source. chemical reaction also considered by use concentration equation. symmetry ...

Arsenic contamination of groundwater occurs due to both geogenic and anthropogenic processes. Conventional arsenic remediation techniques require extraction into pump-and-treat systems, which are expensive long operational times. Hence, there is a need for cost-effective remediation. In this study, we assessed validated the in situ resources using permeable reactive barriers (PRBs) made injecta...

Current standardized testing on air-permeable multilayer cladding is inaccurate since one of the primary parameters for setting the peak net wind loads across the cladding is the external pressure gradient, which is removed from all standardized testing. After implementing a latex-barrier system and examining the control strategy for the pressure loading actuators, a multichamber airbox system ...

The permeability barrier of nuclear pore complexes (NPCs) controls all nucleo-cytoplasmic exchange. It is freely permeable for small molecules. Objects larger than approximately 30 kDa can efficiently cross this barrier only when bound to nuclear transport receptors (NTRs) that confer translocation-promoting properties. We had shown earlier that the permeability barrier can be reconstituted in ...