The BCR-ABL kinase inhibitor, imatinib mesylate, is the front-line treatment for chronic myeloid leukemia, but the emergence of imatinib resistance has led to the search for alternative drug treatments. There is a pressing need, therefore, to develop and test novel drugs. Natural products including plants, microorganisms, and halobios provide rich resources for discovery of anticancer drugs. In...

We measure the diffuse reflection spectrum of solid samples such as explosives (TNT, RDX, PETN), fertilizers (ammonium nitrate, urea), and paints (automotive and military grade) at a stand-off distance of 5 m using a mid-infrared supercontinuum light source with 3.9 W average output power. The output spectrum extends from 750-4300 nm, and it is generated by nonlinear spectral broadening in a 9 ...

Propellants, Explosives, PyrotechnicsVolume 46, Issue 1 p. 1-1 Cover PictureFree Access Picture: (Prop., Explos., Pyrotech. 1/2021) First published: 11 January 2021 https://doi.org/10.1002/prep.202180101Citations: 6AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text full-text accessPlease review our Terms and Conditions of Use chec...

Nine blasts with cylindrical granite specimens were carried out under different stemming conditions. All rock had a diameter of 240 mm and length 300 mm. Explosive Pentaerythritol tetranitrate (PETN) specific charges 0.2 0.3 kg/m3 used, the in large explosion chamber. Each specimen was enclosed by steel box chamber during blasting, without constraint or confinement to from lateral top sides. Du...

Abstract cis-1,3,4,6-tetranitro-octahydroimidazo-[4,5-d]imidazole (BCHMX) was investigated as an energetic filler with three different plastic explosives based on matrices: C4 matrix, semtex10 matrix and EPX matrix. The original explosives, composition including RDX (1,3,5-trinitro-1,3,5-triazinane), Semtex 10 explosive PETN (pentaerythritoltetranitrate) RDX-silicone were included for compariso...

An optical system has been redesigned and used to measure detonation velocity as a function of condensed explosive density for RDX, HMX, PETN. These measurements are then used to determine and fine tune parameters appearing in the BKW (Beker-Kistiakowsky-Wilson) equation of state for gases at extremely high pressures. Steady state form of conservation equations along with the BKW state equation...